Browsing by Subject "ER Stress"
Now showing items 1-6 of 6
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AMPK Activation Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro
( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Background: Chronic kidney disease (CKD) is characterized by progressive decline in renal function; if left untreated, it ultimately results in end-stage renal disease (ESRD), a condition that demands either dialysis or ... -
Metformin Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro
( Wiley Periodicals, Inc , 2017 , Article)Proteinuria (albuminuria) plays a crucial role in the etiology of chronic kidney disease (CKD) via alteration of multiple signaling pathways and cellular process in renal cells. The objectives of this study are to investigate ... -
Nephroprotective Effects of Metformin in Diabetic Nephropathy
( Wiley , 2017 , Article)Metformin, a well-known anti-diabetic agent, is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side-effects. Metformin is also being recommended in the treatment of obesity and ... -
PROTECTIVE EFFECTS OF METFORMIN IN AN IN VITRO MODEL OF PROTEINURIC KIDNEY DISEASE
(2017 , Master Thesis)Albuminuria, a hallmark of chronic kidney disease (CKD), plays a crucial role in the etiology of CKD. High albumin levels are thought to induce endoplasmic reticulum (ER) stress and activate the AKT pathway, and lead to ... -
Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
( Hindawi , 2017 , Article)Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, ... -
Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress
(2015 , Master Thesis)Background: Endoplasmic reticulum (ER) is the chief organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease (CKD). Thus, there is ...