Browsing by Subject "Hyperglycemia"
Now showing items 1-7 of 7
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Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes
( Elsevier , 2023 , Article)AimCardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability ... -
Experimental Diabetes Mellitus in Different Animal Models
( Hindawi , 2016 , Article)Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo. ... -
Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin ... -
Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response
( Elsevier B.V. , 2024 , Article)The unfolded protein response (UPR) detects increased misfolded proteins and activates protein refolding, protein degradation and inflammatory responses. UPR sensors in the endoplasmic reticulum, IRE1α and PERK, bind and ... -
Investigating the effect of hyperglycemia on embryonic heart development using the chick embryo model
( Qatar University Press , 2020 , Poster)Congenital heart defects (CHDs) represent the most common form of human birth defects. Maternal diabetes increases the risk of CHD by 3-5 folds. During heart development, little is known about the effects of high blood ... -
Investigating the efficacy of natural blood glucose lowering compounds in the prevention of congenital heart defects during maternal diabetes using the chick embryo
( Qatar University Press , 2020 , Poster)Diabetes is a metabolic disorder that is characterized by hyperglycemia. Although there are several drugs available for diabetes, patients tend to follow natural remedies. However, the use of these natural remedies lacks ... -
Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells
( Elsevier , 2021 , Article)Hyperglycemia exerts various harmful effects on the vasculature. Studies have shown an association between the levels of the adipokines leptin and adiponectin (APN) and vascular complications in diabetes mellitus. The aim ...