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Landscape of NAT2 polymorphisms among breast cancer.
(
Elsevier Masson
, 2016 , Article)
PURPOSE:
The prevalence of phenotypes of Arylamine N-acetyltransferase-2(NAT2) gene (i.e. fast, intermediate and slow acetylators) among ethnic groups, as well as the association studies regarding NAT2 polymorphisms and ...
Common and Rare Genetic Variants Associated With Alzheimer's Disease
(
WILEY PERIODICALS, INC.
, 2016 , Article)
Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis ...
PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals.
(
Impact Journals
, 2016 , Article)
Platelet derived growth factor receptors (PDGFRs) play an important role in tumor pathogenesis, and they are frequently overexpressed in glioblastoma (GBM). Earlier we have shown a higher protein expression of PDGFR isoforms ...
Recent Perspective About the Amyloid Cascade Hypothesis and Stem Cell-Based Therapy in the Treatment of Alzheimer's Disease
(
Bentham Science
, 2016 , Book chapter)
Alzheimer's disease (AD) is a complex neurodegenerative condition that is
clinically characterized by impaired cognitive functions. The major morphologically
observed lesion of AD encompasses the accumulation of extracellular ...
The effect of triiodothyronine on maturation and differentiation of oligodendrocyte progenitor cells during remyelination following induced demyelination in male albino rat
(
Elsevier, Ltd
, 2016 , Article)
Demyelination was induced by two weeks cuprizone treatment. Rats of +ve control and triiodothyronine (T3) then received three subcutaneous injections of either saline or T3 day after day and sacrificed at the end of the ...
Human Olfactory Bulb Neural Stem Cells Expressing hNGF Restore Cognitive Deficit in Alzheimer's Disease Rat Model
(
Wiley
, 2015 , Article)
In this study, we aim to demonstrate the fate of allogenic adult human olfactory bulb neural stem/progenitor cells (OBNSC/NPCs)
transplanted into the rat hippocampus treated with ibotenic acid (IBO), a neurotoxicant ...
Human microbiome and its association with health and diseases
(
Wiley
, 2016 , Article)
Human microbiota are distinct communities of microorganisms that resides at different body
niches. Exploration of the human microbiome has become a reality due to the availability of
powerful metagenomics and metatranscriptomic ...
Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies.
(
Future Medicine
, 2015 , Article)
Antimicrobial resistance is one of the most serious public health issues facing humans since the discovery of antimicrobial agents. The frequent, prolonged, and uncontrolled use of antimicrobial agents are major factors ...
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)
(
BioMed Central
, 2016 , Article)
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely ...
Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches
(
Springer
, 2021 , Article Review)
We give a summary of SARS-genetic CoV-2’s structure and evolution, as well as current attempts to develop efficient vaccine and treatment methods for SARS-CoV-2 infection, in this article. Most therapeutic strategies are ...