Evaluation of the Cytotoxic Behavior of Fungal Extracellular Synthesized Ag Nanoparticles Using Confocal Laser Scanning Microscope
| Author | Salaheldin, Taher A. |
| Author | Husseiny, Sherif M. |
| Author | Al-Enizi, Abdullah M. |
| Author | Elzatahry, Ahmed |
| Author | Cowley, Alan H. |
| Available date | 2016-10-24T10:08:11Z |
| Publication Date | 2016-03-03 |
| Publication Name | International Journal of Molecular Science |
| Identifier | http://dx.doi.org/10.3390/ijms17030329 |
| Citation | Salaheldin, T.A.; Husseiny, S.M.; Al-Enizi, A.M.; Elzatahry, A.; Cowley, A.H. Evaluation of the Cytotoxic Behavior of Fungal Extracellular Synthesized Ag Nanoparticles Using Confocal Laser Scanning Microscope. Int. J. Mol. Sci. 2016, 17, 329. |
| Abstract | Silver nanoparticles have been synthesized by subjecting a reaction medium to a Fusarium oxysporum biomass at 28 °C for 96 h. The biosynthesized Ag nanoparticles were characterized on the basis of their anticipated peak at 405 nm using UV-Vis-NIR spectroscopy. Structural confirmation was evident from the characteristic X-ray diffraction (XRD) pattern, high-resolution transmission electron Microscopy (HRTEM) and the particle size analyzer. The Ag nanoparticles were of dimension 40 ± 5 nm and spherical in shape. The study mainly focused on using the confocal laser scanning microscope (CLSM) to examine the cytotoxic activities of fungal synthesized Ag nanoparticles on a human breast carcinoma cell line MCF7 cell, which featured remarkable vacuolation, thus indicating a potent cytotoxic activity. |
| Sponsor | Deanship of Scientific Research at King Saud University for its funding this Prolific Research group (PRG-1436-14). |
| Language | en |
| Publisher | MDPI AG |
| Subject | silver nanoparticles cytotoxicity breast cancer confocal laser scanning microcopy |
| Type | Article |
| Issue Number | 3 |
| Volume Number | 17 |
| ESSN | 1422-0067 |
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