Browsing Laboratory Animal Research Center by Publication Date
Now showing items 21-40 of 91
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Novel potentials of the DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in rat ex-vivo heart model
( MDPI AG , 2018 , Article)Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral anti-diabetic drugs, implicated in pleiotropic secondary cardioprotective effects. The aim of the study was to unveil the unknown and possible cardioprotective ... -
Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats
( Scientific Research Publishing , 2018 , Article)Diet plays a major role in the body physiology and metabolism. The quantity, nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a ... -
RAS-mediated oncogenic signaling pathways in human malignancies
( Elsevier , 2018 , Article Review)Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its ... -
Quality of Drinking water in Qatar University Rodent vivarium
(2018 , Poster)Edstrom watering system was newly installed and all the accessories were used for limited run, but gradually the system runs continuously and this improved the water quality . Moreover our microbial count of water samples ... -
Effect of psoriasis linked CARMA2sh gene in transgenic animal model
(2018 , Poster)Background • CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB, that has a central role in controlling the immune and inflammatory response, cell survival and ... -
Sugar alcohol provides imaging contrast in cancer detection
( NLM (Medline) , 2019 , Article)Clinical imaging is widely used to detect, characterize and stage cancers in addition to monitoring the therapeutic progress. Magnetic resonance imaging (MRI) aided by contrast agents utilizes the differential relaxivity ... -
Single-Voxel H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD ) in humans at 7T using a 32-channel volume coil.
( Wiley , 2019 , Article)Reliable monitoring of tissue nicotinamide adenine dinucleotide (NAD ) concentration may provide insights on its roles in normal and pathological aging. In the present study, we report a H MRS pulse sequence for the in ... -
Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury
( Scientific Research Publishing , 2019 , Article Review)Cadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing ... -
Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.
( Frontiers Media , 2019 , Article)The ability of epithelial cells to organize through cell-cell adhesion into a functioning epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent cells are made up of tight junctions ... -
Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance.
( Springer Verlag , 2019 , Article)The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of the tumor ... -
Gut Microbiota Dysbiosis and Their Impact on Biochemical and Inflammatory Profiles in Cafeteria Diet Fed Sprague Dawley Rats
( Scientific Research Publishing , 2019 , Article)Gut microbiota plays a major role in regulating the host metabolism and immune system. However, the structure of microbiome population is altered constantly by diverse factors including diet and environment. In particular, ... -
Association of genes with phenotype in autism spectrum disorder.
( Impact Journals , 2019 , Article Review)Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder that is characterized by impairments in social interaction and speech development and is accompanied by stereotypical behaviors such as ... -
Gut Microbiota and Health: Understanding the Role of Diet
( Scientific Research Publishing , 2019 , Article Review)Microbiome now is considered as an organ within our system to regulate metabolism, cellular immune response and eventually maintain the health. Gut microbiota has been studied extensively in the recent past due to the ... -
Role of animal research in human malignancies
( Elsevier , 2019 , Book chapter)Animal models are the central backbone in relation to providing the safety information of xenobiotics, the nature of chemicals present in the environment, and understanding the developmental process in disease pathogenesis ... -
Functional In Vivo Imaging of Tumors.
( Springer , 2020 , Book chapter)Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the ... -
1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo
( Nature Research , 2020 , Article)Quantitative mapping of the in vivo dynamics of cellular metabolism via non-invasive imaging contributes to our understanding of the initiation and progression of diseases associated with dysregulated metabolic processes. ... -
Exploring Dysregulated Signaling Pathways in Cancer.
( Bentham Science Publishers , 2020 , Article Review)Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from the exterior of cell to intracellular ... -
Claudin-1, A Double-Edged Sword in Cancer.
( MDPI , 2020 , Article Review)Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated ... -
Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers
( Elsevier , 2020 , Article)IntroductionAntiretroviral therapy (ART) is considered the most effective way to prevent perinatal transmission of human immunodeficiency virus (HIV). However, there is little knowledge about the effect of ART on the brain ... -
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance.
( BMC , 2020 , Article Review)Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia ...
