Browsing by Author "Zeidan, Asad"
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Activation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.
Djouhri, Laiche; Malki, MohammedImad; Zeidan, Asad; Nagi, Karim; Smith, Trevor ( Taylor & Francis (Routledge) , 2019 , Article)Diabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of ... -
Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an in vivo mouse model
Kobeissy, Firas; Shaito, Abdullah; Kaplan, Abdullah; Baki, Lama; Hayek, Hassan; Dagher-Hamalian, Carole; Nehme, Ali; Ghali, Rana; Abidi, Emna; Husari, Ahmad; Zeidan, Asad; Zouein, Fouad A.; Zibara, Kazem... more authors ... less authors ( Hindawi Limited , 2017 , Article)Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial ... -
Advances in Cardiovascular Biomarker Discovery.
Ghantous, Crystal M; Kamareddine, Layla; Farhat, Rima; Zouein, Fouad A; Mondello, Stefania; Kobeissy, Firas; Zeidan, Asad... more authors ... less authors ( MDPI , 2020 , Article Review)Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart ... -
BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells.
Alhoshani, Ali; Alatawi, Fahad O; Al-Anazi, Fawaz E; Attafi, Ibraheem M; Zeidan, Asad; Agouni, Abdelali; El Gamal, Heba M; Shamoon, Licia S; Khalaf, Sarah; Korashy, Hesham M... more authors ... less authors ( Dove Medical Press , 2020 , Article)Venetoclax (VCX) is a selective BCL-2 inhibitor approved for the treatment of leukemia and lymphoma. However, the mechanisms of anti-cancer effect of VCX either as a monotherapy or in combination with other chemotherapeutic ... -
Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
Kamareddine, Layla; Ghantous, Crystal; Allouch, Soumaya; Al-Ashmar, Sara; Anlar, Gulsen; Kannan, Surya; Djouhri, Laiche; Korashy, Hesham; Agouni, Abdelali; Zeidan, Asad... more authors ... less authors ( Dove Medical Press , 2021 , Article Review)Cardiac remodeling is the process by which the heart adapts to stressful stimuli, such as hypertension and ischemia/reperfusion; it ultimately leads to heart failure upon long- term exposure. Autophagy, a cellular catabolic ... -
Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy
Laiche, Djouhri; Zeidan, Asad; Abd El-Aleem, Seham A. ( Elsevier , 2020 , Article)Diabetic peripheral neuropathic pain (DPNP), the most debilitating complication of diabetes mellitus, is resistant to current therapy. The pathogenesis of DPNP is still elusive, but several mechanisms have been proposed ... -
Cutaneous Aβ-Non-nociceptive, but Not C-Nociceptive, Dorsal Root Ganglion Neurons Exhibit Spontaneous Activity in the Streptozotocin Rat Model of Painful Diabetic Neuropathy .
Djouhri, Laiche; Zeidan, Asad; Abd El-Aleem, Seham A; Smith, Trevor ( Frontiers Media , 2020 , Article)Diabetic peripheral neuropathic pain (DPNP) is the most devastating complication of diabetes mellitus. Unfortunately, successful therapy for DPNP remains a challenge because its pathogenesis is still elusive. However, DPNP ... -
Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway
Maram, Hasan; Al-Thani, Hassan; El-Menyar, Ayman; Zeidan, Asad; Al-Thani, Asmaa; Yalcin, Huseyin C.... more authors ... less authors ( Elsevier , 2023 , Article Review)Hemodynamic shear stress is one of the major factors that are involved in the pathogenesis of many cardiovascular diseases including atherosclerosis and abdominal aortic aneurysm (AAA), through its modulatory effect on the ... -
EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
Alhoshani, Ali; Alanazi, Fawaz E; Alotaibi, Moureq R; Attwa, Mohamed W; Kadi, Adnan A; Aldhfyan, Abdullah; Akhtar, Sabah; Hourani, Shireen; Agouni, Abdelali; Zeidan, Asad; Korashy, Hesham M... more authors ... less authors ( American Chemical Society , 2020 , Article)Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ... -
Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival.
Osman, Aisha; El-Gamal, Heba; Pasha, Mazhar; Zeidan, Asad; Korashy, Hesham M; Abdelsalam, Shahenda S; Hasan, Maram; Benameur, Tarek; Agouni, Abdelali... more authors ... less authors ( Frontiers Media , 2020 , Article)Circulating extracellular vesicles (EVs) are recognized as biomarkers and effectors of endothelial dysfunction, the initiating step of cardiovascular abnormalities. Among these EVs, microparticles (MPs) are vesicles directly ... -
Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes.
Maamoun, Hatem; Abdelsalam, Shahenda S; Zeidan, Asad; Korashy, Hesham M; Agouni, Abdelali ( MDPI , 2019 , Article)Physical inactivity and sedentary lifestyle contribute to the widespread epidemic of obesity among both adults and children leading to rising cases of diabetes. Cardiovascular disease complications associated with obesity ... -
Enteric pathogens modulate metabolic homeostasis in the Drosophila melanogaster host
Hoda, Najjar; Al-Ashmar, Sarah; Qush, Abeer; Al-Asmar, Jawaher; Rashwan, Sara; Elgamal, Abdelrahman; Zeidan, Asad; Kamareddine, Layla... more authors ... less authors ( Elsevier , 2022 , Article)On quotidian basis, living beings work out an armistice with their microbial flora and a scuffle with invading pathogens to maintain a normal state of health. Although producing virulence factors and escaping the host's ... -
Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway
Sabah, Akhtar; Hourani, Shireen; Therachiyil, Lubna; Al-Dhfyan, Abdullah; Agouni, Abdelali; Zeidan, Asad; Uddin, Shahab; Korashy, Hesham M.... more authors ... less authors ( Elsevier , 2020 , Article)Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that has been proposed as a strong sustainer and promoter of tumorigenesis and ... -
Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction
Osman, Aisha; Benameur, Tarek; Korashy, Hesham M.; Zeidan, Asad; Agouni, Abdelali ( MDPI , 2020 , Article)Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded protein response (UPR), aiming at ... -
Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells
Ola, El Atab; Ghantous, Crystal M.; El-Zein, Nabil; Farhat, Rima; Agouni, Abdelali; Korashy, Hesham M.; Djouhri, Laiche; Kamareddine, Layla; Zibara, Kazem; Zeidan, Asad... more authors ... less authors ( Elsevier , 2021 , Article)Hyperglycemia exerts various harmful effects on the vasculature. Studies have shown an association between the levels of the adipokines leptin and adiponectin (APN) and vascular complications in diabetes mellitus. The aim ... -
L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats .
Djouhri, Laiche; Zeidan, Asad; Alzoghaibi, Mohammad; Al Otaibi, Mohammad F; Abd El-Aleem, Seham A ( Mary Ann Liebert , 2020 , Article)Peripheral neuropathic pain (PNP) is a major health problem for which effective drug treatment is lacking. Its underlying neuronal mechanisms are still illusive, but pre-clinical studies using animal models of PNP including ... -
MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
Hourani, Shireen Bayan (2021 , Master Thesis)Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. Chemoresistance is attributed to the presence of long-lived cancer stem cells (CSCs) responsible for therapy failure. This study ... -
Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
Ghantous, Crystal M.; Farhat, Rima; Djouhri, Laiche; Alashmar, Sarah; Anlar, Gulsen; Korashy, Hesham M.; Agouni, Abdelali; Zeidan, Asad... more authors ... less authors ( hindawi , 2020 , Article)Hypertension induces vascular hypertrophy, which changes blood vessels structurally and functionally, leading to reduced tissue perfusion and further hypertension. It is also associated with dysregulated levels of the ... -
Myocardial proteases and cardiac remodeling
Riaz, Sadaf; Zeidan, Asad; Mraiche, Fatima ( Wiley-Liss Inc. , 2017 , Article Review)Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need ... -
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress-impaired endothelial cell angiogenic response: A critical role for cell survival
ABDELSALAM, SHAHENDA S.; PASHA, MAZHAR; EL-GAMAL, HEBA; HASAN, MARAM; ELRAYESS, MOHAMED A.; ZEIDAN, ASAD; KORASHY, HESHAM M.; AGOUNI, ABDELALI... more authors ... less authors ( Spandidos publications , 2021 , Article)Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is ...