Browsing by Author "Hammoud, Safaa H."
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Adipose tissue immunomodulation: A novel therapeutic approach in cardiovascular and metabolic diseases
Alzaim, Ibrahim; Hammoud, Safaa H.; Al-Koussa, Houssam; Ghazi, Alaa; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( Frontiers Media , 2020 , Article)Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As the main storage pool of lipids, ... -
Corrigendum to “Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs” [Biochem. Pharmacol. 186 (2021) 114491]
Hammoud, Safaa H.; AlZaim, Ibrahim; Mougharbil, Nahed; Koubar, Sahar; Eid, Ali H.; Eid, Assaad A.; El-Yazbi, Ahmed F.... more authors ... less authors ( Elsevier , 2023 , Other)We regret to report that a mistake occurred in preparation of Fig. 4. The modified figure is included below. We apologize for any confusion this might have created. -
Dysregulation of angiotensin converting enzyme 2 expression and function in comorbid disease conditions possibly contributes to coronavirus infectious disease 2019 complication severity
Hammoud, Safaa H.; Wehbe, Zena; Abdelhady, Samar; Kobeissy, Firas; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( American Society for Pharmacology and Experimental Therapy , 2021 , Article Review)ACE2 has emerged as a double agent in the COVID-19 ordeal, as it is both physiologically protective and virally conducive. The identification of ACE2 in as many as 72 tissues suggests that extrapulmonary invasion and damage ... -
Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration
Al-Saidi, Aya; Alzaim, Ibrahim F.; Hammoud, Safaa H.; Arab, Ghida Al; Abdalla, Samaya; Mougharbil, Nahed; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( Portland Press Ltd , 2024 , Article)The cardiovascular and renovascular complications of metabolic deterioration are associated with localized adipose tissue dysfunction. We have previously demonstrated that metabolic impairment delineated the heightened ... -
Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
Hammoud, Safaa H.; AlZaim, Ibrahim; Mougharbil, Nahed; Koubar, Sahar; Eid, Ali H.; Eid, Assaad A.; El-Yazbi, Ahmed F.... more authors ... less authors ( Elsevier , 2021 , Article)Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients’ quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines ... -
Perirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases
Hammoud, Safaa H.; AlZaim, Ibrahim; Al-Dhaheri, Yusra; Eid, Ali H.; El-Yazbi, Ahmed F. ( Frontiers Media S.A. , 2021 , Article)A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it contributes to energy homeostasis and provides insulation for internal organs. Adipocytes were previously thought to be a passive ... -
The pleiotropic effects of antithrombotic drugs in the metabolic-cardiovascular-neurodegenerative disease continuum: Impact beyond reduced clotting
Alaaeddine, Rana A.; AlZaim, Ibrahim; Hammoud, Safaa H.; Arakji, Aya; Eid, Ali H.; Abd-Elrahman, Khaled S.; El-Yazbi, Ahmed F.... more authors ... less authors ( Portland Press Ltd , 2021 , Article Review)Antithrombotic drugs are widely used for primary and secondary prevention, as well as treatment of many cardiovascular disorders. Over the past few decades, major advances in the pharmacology of these agents have been made ... -
Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue
Alzaim, Ibrahim; Al-Saidi, Aya; Hammoud, Safaa H.; Darwiche, Nadine; Al-Dhaheri, Yusra; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( MDPI , 2022 , Article)The increased global prevalence of metabolic disorders including obesity, insulin resistance, metabolic syndrome and diabetes is mirrored by an increased incidence of prostate cancer (PCa). Ample evidence suggests that ...