Browsing by Author "Tayubi, Iftikhar Aslam"
Now showing items 1-6 of 6
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A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis
Udhaya Kumar, S.; Saleem, Aisha; Thirumal Kumar, D.; Anu Preethi, V.; Younes, Salma; Zayed, Hatem; Tayubi, Iftikhar Aslam; George Priya Doss, C.... more authors ... less authors ( Elsevier , 2021 , Book chapter)Background and aim: The persistence of extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (MTB) continue to pose a significant challenge to the treatment and control of tuberculosis infections worldwide. ... -
A comparative computational approach toward pharmacological chaperones (NN-DNJ and ambroxol) on N370S and L444P mutations causing Gaucher's disease.
Thirumal Kumar, D; Iyer, Sharada; Christy, J Priyadharshini; Siva, R; Tayubi, Iftikhar Aslam; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Book chapter)Gaucher's disease (GD) is the most commonly known lysosomal disorder that occurs due to mutations in the β-glucocerebrosidase (GBA) protein. Our previous findings (Thirumal Kumar, Eldous, Mahgoub, George Priya Doss, Zayed, ... -
Computational and modeling approaches to understand the impact of the Fabry's disease causing mutation (D92Y) on the interaction with pharmacological chaperone 1-deoxygalactonojirimycin (DGJ).
Thirumal Kumar, D; Judith, E; Priyadharshini Christy, J; Siva, R; Tayubi, Iftikhar Aslam; Chakraborty, Chiranjib; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Book chapter)Fabry's disease (FD) is the second most commonly occurring lysosomal storage disorders (LSDs). The mutations in α-galactosidase A (GLA) protein were widely found to be causative for the Fabry's disease. These mutations ... -
A computational overview on phylogenetic characterization, pathogenic mutations, and drug targets for Ebola virus disease
Vasudevan, Karthick; D, Thirumal Kumar; S, Udhaya Kumar; Saleem, Aisha; N, Nagasundaram; R, Siva; Tayubi, Iftikhar Aslam; Doss, C. George Priya; Zayed, Hatem... more authors ... less authors ( Elsevier , 2021 , Article)The World Health Organization declared Ebola virus disease(EVD) as the major outbreak in the 20th century. EVD was firstidentified in 1976 in South Sudan and the Democratic Republicof the Congo. EVD was transmitted from ... -
Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease
Sundarrajan, Sudharsana; Venkatesan, Arthi; Kumar S, Udhaya; Gopikrishnan, Mohanraj; Tayubi, Iftikhar Aslam; Aditya, M.; Siddaiah, Gowrishankar Bychapur; George Priya Doss, C.; Zayed, Hatem... more authors ... less authors ( Springer Nature , 2023 , Article)Alzheimer disease (AD) is a leading cause of dementia in elderly patients who continue to live between 3 and 11 years of diagnosis. A steep rise in AD incidents is observed in the elderly population in East-Asian countries. ... -
Understanding the structure-function relationship of HPRT1 missense mutations in association with Lesch-Nyhan disease and HPRT1-related gout by in silico mutational analysis.
Agrahari, Ashish Kumar; Krishna Priya, M; Praveen Kumar, Medapalli; Tayubi, Iftikhar Aslam; Siva, R; Prabhu Christopher, B; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Article)The nucleotide salvage pathway is used to recycle degraded nucleotides (purines and pyrimidines); one of the enzymes that helps to recycle purines is hypoxanthine guanine phosphoribosyl transferase 1 (HGPRT1). Therefore, ...