Browsing by Author "Rizeq, Balsam"
Now showing items 1-12 of 12
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Circulating miRNAs in HER2-Positive and Triple Negative Breast Cancers: Potential Biomarkers and Therapeutic Targets.
Gupta, Ishita; Rizeq, Balsam; Vranic, Semir; Moustafa, Ala-Eddin Al; Al Farsi, Halema ( MDPI , 2020 , Article)Breast cancer is one of the most prevalent diseases among women worldwide and is highly associated with cancer-related mortality. Of the four major molecular subtypes, HER2-positive and triple-negative breast cancer (TNBC) ... -
Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo
Maha, Al-Asmakh; Bawadi, Hiba; Hamdan, Munia; Gupta, Ishita; Kheraldine, Hadeel; Jabeen, Ayesha; Rizeq, Balsam; Al Moustafa, Ala-Eddin... more authors ... less authors ( Elsevier , 2021 , Article)Dasatinib is a targeted cancer therapy, while programmed death ligand 1 (PD-L1) inhibitors are a form of immune checkpoint therapy used to treat various types of cancers. Several studies showed the potential efficacy of ... -
Mesoporous silica coated carbon nanofibers reduce embryotoxicity via ERK and JNK pathways
Abdo, Ghada G.; Gupta, Ishita; Kheraldine, Hadeel; Rizeq, Balsam; Zagho, Moustafa M.; Khalil, Ashraf; Elzatahry, Ahmed; Al Moustafa, Ala-Eddin... more authors ... less authors ( Elsevier Ltd , 2021 , Article)Carbon nanofibers (CNFs) have been implicated in biomedical applications, yet, they are still considered as a potential hazard. Conversely, mesoporous silica is a biocompatible compound that has been used in various ... -
Novel CD44-downstream signaling pathways mediating breast tumor invasion
Ouhtit, Allal; Rizeq, Balsam; Abou Saleh, Haissam; Rahman, MD Mizanur; Zayed, Hatem ( Ivyspring International Publisher , 2018 , Article Review)CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including ... -
Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways
Rizeq, Balsam; Gupta, Ishita; Kheraldine, Hadeel; Elkhalifa, Dana; Al-Farsi, Halema F.; Moustafa, Ala-Eddin A.; Khalil, Ashraf... more authors ... less authors ( MDPI , 2021 , Article)Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our ... -
Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion
Rizeq, Balsam; Sif, Saïd; Nasrallah, Gheyath K; Ouhtit, Allal ( Wiley Open Access , 2020 , Article)Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%-10% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting the ... -
Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
Hussein, Essraa; Zagho, Moustafa; Rizeq, Balsam; Younes, Nadin; Pintus, Gianfranco; Mahmoud, Khaled; Nasrallah, Gheyath; Elzatahry, Ahmed... more authors ... less authors ( DOVE Medical Press , 2019 , Article)Purpose: Here, we fabricated two plasmonic 2D Ti3C2Tx-based nanocomposites (Au/MXene and Au/Fe3O4/MXene) with similarly high anti-cancer photothermal therapy (PTT) capabilities, but with less in vivo toxicity than a pure ... -
The Role of CCL21/CCR7 Chemokine Axis in Breast Cancer Progression
Malki, Mohammed Imad; Rizeq, Balsam ( MDPI , 2015 , Article Review)Tumor-induced lymphangiogenesis facilitates breast cancer progression by generating new lymphatic vessels that serve as conduits for tumor dissemination to lymph nodes and beyond. Given the recent evidence suggesting the ... -
SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities.
Gupta, Ishita; Rizeq, Balsam; Elkord, Eyad; Vranic, Semir; Al Moustafa, Ala-Eddin ( MDPI , 2020 , Article Review)Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to ... -
Significant Toxic Effect of Carbon Nanofibers at the Early Stage of Embryogenesis
Abdo, Ghada G.; Kheraldine, Hadeel; Gupta, Ishita; Rizeq, Balsam; Elzatahry, Ahmed; Al Moustafa, Ala-Eddin; Khalil, Ashraf... more authors ... less authors ( NLM (Medline) , 2020 , Article)Implementation of carbon nanofibers (CNFs) in biomedical applications have successful outcomes, however, they are still considered as a potential hazard. We herein used avian embryos at 3 days and its chorioallantoic ... -
The power of phytochemicals combination in cancer chemoprevention
Rizeq, Balsam; Gupta, Ishita; Ilesanmi, Josephine; AlSafran, Mohammed; Rahman, MD Mizanur; Ouhtit, Allal... more authors ... less authors ( Ivyspring International Publisher , 2020 , Article Review)Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ... -
Towards understanding the mechanisms of actions of carcinoembryonic antigen-related cell adhesion molecule 6 in cancer progression
Rizeq, Balsam; Zakaria, Zain; Ouhtit, Allal ( Wiley Open Access , 2017 , Article Review)Human carcinoembryonic antigen (CEA) is the prototypic member of a family of highly related cell surface glycoproteins that includes carcinoembryonic antigenrelated cell adhesion molecule 6 (CEACAM6) and others. CEACAM6 ...