تصفح حسب المؤلف "Abu-Dawud, Raed"
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Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains
Kashir, Junaid; Mistry, Bhavesh; Gumssani, Maha; Rajab, Muhammad; Abu-Dawas, Reema; Almohanna, Falah; Nomikos, Michail; Jones, Celine; Abu-Dawud, Raed; Al-Yacoub, Nadya; Coward, Kevin; Lai, F.; Assiri, Abdullah... more authors ... less authors ( Medknow Publications , 2021 , Article)Sperm-specific phospholipase C zeta (PLC) initiates intracellular calcium (Ca2+) transients which drive a series of concurrent events collectively termed oocyte activation. Numerous investigations have linked abrogation ... -
Antigen Unmasking Is Required to Clinically Assess Levels and Localisation Patterns of Phospholipase C Zeta in Human Sperm
Kashir, Junaid; Mistry, Bhavesh V.; BuSaleh, Lujain; Nomikos, Michail; Almuqayyil, Sarah; Abu-Dawud, Raed; AlYacoub, Nadya; Hamdan, Hamdan; AlHassan, Saad; Lai, F. Anthony; Assiri, Abdullah M.; Coskun, Serdar... more authors ... less authors ( MDPI , 2023 , Article)Mammalian oocyte activation is initiated by intracellular calcium (Ca2+) oscillations, driven by the testis-specific phospholipase C zeta (PLCζ). Sperm PLCζ analysis represents a diagnostic measure of sperm fertilisation ... -
Phospholipase C zeta profiles are indicative of optimal sperm parameters and fertilisation success in patients undergoing fertility treatment.
Kashir, Junaid; Mistry, Bhavesh V; BuSaleh, Lujain; Abu-Dawas, Reema; Nomikos, Michail; Ajlan, Ahmed; Abu-Dawud, Raed; AlYacoub, Nadya; AlHassan, Saad; Lai, F Anthony; Assiri, Abdullah M; Coskun, Serdar... more authors ... less authors ( wiley , 2020 , Article)Oocyte activation is driven by intracellular calcium (Ca ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to ...