Browsing by Author "Elshenawy, Osama H."
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Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart
Amara, Issa E.A.; Elshenawy, Osama H.; Abdelrady, Mohamed; El-Kadi, Ayman O.S. ( Elsevier Ireland Ltd. , 2014 , Article)Mercury exposure is associated with increased risk of cardiovascular disease and profound cardiotoxicity. However, the correlation between Hg2+-mediated toxicity and alteration in cardiac cytochrome P450s (Cyp) and their ... -
Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms
Anwar-Mohamed, Anwar; Elshenawy, Osama H.; Soshilov, Anatoly A.; Denison, Michael S.; Le, X. Chris; Klotz, Lars-Oliver; El-Kadi, Ayman O.S.... more authors ... less authors ( Elsevier Inc. , 2014 , Article)Activation of the aryl hydrocarbon receptor (AhR) ultimately leads to the induction of the carcinogen-activating enzyme cytochrome P450 1A1 (CYP1A1), and activation of the nuclear factor-erythroid 2 p45-related factor 2 ...