Browsing by Author "Zayed, Hatem"
Now showing items 41-60 of 134
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Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17–36 epitopes
Jagu, Subhashini; Karanam, Balusubramanyam; Wang, Joshua W.; Zayed, Hatem; Weghofer, Margit; Brendle, Sarah A.; Balogh, Karla K.; Tossi, Kerstin Pino; Roden, Richard B.S.; Christensen, Neil D.... more authors ... less authors ( Elsevier, Ltd , 2015 , Article)Vaccination with the minor capsid protein L2, notably the 17–36 neutralizing epitope, induces broadly protective antibodies, although the neutralizing titers attained in serum are substantially lower than for the licensed ... -
Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients - A Bioinformatics Approach.
Udhaya Kumar, S; Thirumal Kumar, D; Siva, R; George Priya Doss, C; Younes, Salma; Younes, Nadin; Sidenna, Mariem; Zayed, Hatem... more authors ... less authors ( Frontiers Media , 2020 , Article)Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder that is clinically complex and has increased production of autoantibodies. Via emerging technologies, researchers have identified genetic variants, ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations.
Ramli, Iman; Posadino, Anna Maria; Giordo, Roberta; Fenu, Grazia; Fardoun, Manal; Iratni, Rabah; Eid, Ali H; Zayed, Hatem; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2023 , Article Review)Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ... -
Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach.
Thirumal Kumar, D; Susmita, B; Judith, E; Priyadharshini Christy, J; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Article)The DNA repair system is crucial to repair the error resulting in DNA replication. MSH2-MSH6 protein complex plays a significant role in maintaining the mismatch repair mechanism. Mutations in the interface between the two ... -
Enhanced Identification of Transcriptional Enhancers Provides Mechanistic Insights into Diseases.
Murakawa, Y; Yoshihara, M; Kawaji, H.; Nishikawa, M; Zayed, Hatem; Suzuki H, Fantom Consortium, Hayashizaki Y.... more authors ... less authors ( Cell Press , 2016 , Article)Enhancers are distal cis-regulatory DNA elements that increase the expression of target genes. Various experimental and computational approaches including chromatin signature profiling have been developed to predict enhancers ... -
Enhanced production of anthraquinones by gamma-irradiated cell cultures of Rubia cordifolia in a bioreactor
A, Mariadoss; Satdive, Ramesh; Fulzele, Devanand P.; Ramamoorthy, Siva; C, George Priya Doss; Zayed, Hatem; Younes, Salma; C, Rajasekaran... more authors ... less authors ( Elsevier , 2019 , Article)The aim of this study was to obtain high-yielding cell cultures of Rubia cordifolia by applying gamma irradiation and subsequently scaling up for anthraquinone production in a bioreactor. Calli cultured on MS medium was ... -
Enzyme therapy: a forerunner in catalyzing a healthy society?
Datta, Saptashwa; Rajnish, K Narayanan; George Priya Doss, C; Melvin Samuel, S; Selvarajan, E; Zayed, Hatem... more authors ... less authors ( Taylor & Francis , 2020 , Article)The use of enzymes in various industries has been prevalent for centuries. However, their potency as therapeutics remained latent until the late 1950 s, when scientists finally realized the gold mine they were sitting on. ... -
Evolving strategies and application of proteins and peptide therapeutics in cancer treatment
Mukherjee, Anirban Goutam; Wanjari, Uddesh Ramesh; Gopalakrishnan, Abilash Valsala; Bradu, Pragya; Biswas, Antara; Ganesan, Raja; Renu, Kaviyarasi; Dey, Abhijit; Vellingiri, Balachandar; El Allali, Achraf; Alsamman, Alsamman M.; Zayed, Hatem; George Priya Doss, C.... more authors ... less authors ( Elsevier , 2023 , Article Review)Several proteins and peptides have therapeutic potential and can be used for cancer therapy. By binding to cell surface receptors and other indicators uniquely linked with or overexpressed on tumors compared to healthy ... -
Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease
Sundarrajan, Sudharsana; Venkatesan, Arthi; Kumar S, Udhaya; Gopikrishnan, Mohanraj; Tayubi, Iftikhar Aslam; Aditya, M.; Siddaiah, Gowrishankar Bychapur; George Priya Doss, C.; Zayed, Hatem... more authors ... less authors ( Springer Nature , 2023 , Article)Alzheimer disease (AD) is a leading cause of dementia in elderly patients who continue to live between 3 and 11 years of diagnosis. A steep rise in AD incidents is observed in the elderly population in East-Asian countries. ... -
An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia
S, Udhaya Kumar; D, Thirumal Kumar; R, Siva; C, George Priya Doss; Zayed, Hatem ( Elsevier , 2019 , Article)Type I galactosemia is a very rare autosomal recessive genetic metabolic disorder that occurs because of the mutations present in the galactose-1-phosphate uridyl transferase (GALT) gene, resulting in a deficiency of the ... -
Fasting Ramadan During COVID-19 Pandemic: Immunomodulatory Effect
Abunada, Taghreed; Abunada, Hanan; Zayed, Hatem ( Frontiers Media S.A. , 2020 , Article)As of April 24, 2020, more than 1. 6 billion Muslims observe the holy fasting month of Ramadan worldwide. The safety of fasting of healthy adult Muslims during the COVID-19 era is debatable. In this perspective, we discuss ... -
Genetic Epidemiology of Beta-Thalassemia in the Maldives: 23 years of a Beta-Thalassemia Screening Program.
Mustafa, Ibrahim; Firdous, Naila; Shebl, Fatma M; Shi, Zumin; Saeed, Mariya; Zahir, Zileena; Zayed, Hatem... more authors ... less authors ( Elsevier , 2020 , Article)The Maldives is an archipelago of 407,660 people according to population census of 2014, made up of 20 atolls, which has one of the highest prevalence of β-thalassemia worldwide. However, there is a dearth of studies related ... -
Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World
Doss, C. George Priya; Alasmar, Dima R.; Bux, Reem I.; Sneha, P.; Bakhsh, Fadheela Dad; Al-Azwani, Iman; El Bekay, Rajaa; Zayed, Hatem... more authors ... less authors ( Nature Publishing Group , 2016 , Article)A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations of Glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDD) ... -
Genetic Epidemiology of Hearing Loss in the 22 Arab Countries: A Systematic Review
Sidenna, Mariem; Fadl, Tasnim; Zayed, Hatem ( Wolters Kluwer Health , 2019 , Article)Hearing loss (HL) is a heterogeneous condition that causes partial or complete hearing impairment. Hundreds of variants in more than 60 genes have been reported to be associated with Hereditary HL (HHL). The HHL prevalence ... -
Genetic epidemiology of male infertility (MI) in Arabs: a systematic review
Okashah, Sarah; Abunada, Taghreed; Zayed, Hatem ( CSIRO , 2022 , Article Review)Although Male Infertility (MI) in Arabs is fairly common, there is a dearth in published reports of genetic epidemiology of MI among Arabs. This study aimed to review the existing literature reporting the variants that are ... -
Genetic epidemiology of ovarian cancer in the 22 Arab countries: A systematic review.
Younes, Nadin; Zayed, Hatem ( Elsevier , 2019 , Article)Ovarian cancer (OC) is a common disease among Arabs, with one of the highest incidences in the world. OC is underdiagnosed, underreported, and mostly reported with breast cancer. This study aimed to conduct a systematic ... -
Genetic Epidemiology of Primary Congenital Glaucoma in the 22 Arab Countries: A Systematic Review.
Jemmeih, Sara; Malik, Shaza; Okashah, Sarah; Zayed, Hatem ( Taylor and Francis , 2021 , Article)Primary congenital glaucoma (PCG) is a rare glaucoma type that develops in early infantile period and contributes to an elevated pressure on ocular cavity. Variants in gene are the most encountered in PCG cases. The ... -
Genetic Epidemiology of Type 1 Diabetes in the 22 Arab Countries.
Zayed, Hatem ( Current Medicine Group , 2016 , Article)Type 1 diabetes (T1D) is a complex autoimmune disorder that results from the T cell-mediated destruction of the pancreatic β cells and is due to interactions between environmental and genetic factors. Although Arabs have ... -
Genetic polymorphisms associated with obesity in the Arab world: a systematic review
Younes, Salma; Ibrahim, Amal; Al-Jurf, Rana; Zayed, Hatem ( Springer Nature , 2021 , Article Review)Background: Obesity, one of the most common chronic health conditions worldwide, is a multifactorial disease caused by complex genetic and environmental interactions. Several association studies have revealed a considerable ... -
Genetic polymorphisms associated with type 2 diabetes in the Arab world: A systematic review and meta-analysis.
Abuhendi, Najat; Qush, Abeer; Naji, Fozieh; Abunada, Hanan; Al Buainain, Reeham; Shi, Zumin; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Article)T2DM reach epidemic levels in the Arab countries. In this study, we aimed to perform a systematic review and meta-analysis to underline the susceptibility genetic profile of Arab patients with T2DM that result from SNPs. ...