Browsing by Author "D., Thirumal Kumar"
Now showing items 1-9 of 9
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Comparison of potential inhibitors and targeting fat mass and obesity-associated protein causing diabesity through docking and molecular dynamics strategies.
S, Udhaya Kumar; Rajan, Bithia; D, Thirumal Kumar; R, Hephzibah Cathryn; V, Samprita Das.; Zayed, Hatem; Walter, Charles Emmanuel Jebaraj; Ramanathan, Gnanasambandan; Doss, George Priya... more authors ... less authors ( Wiley , 2021 , Article)Genome-wide association studies (GWAS) have identified an association between polymorphisms in the FTO gene and obesity. The FTO: rs9939609, an intronic variant, is considered a risk allele for developing diabesity in ... -
A computational overview on phylogenetic characterization, pathogenic mutations, and drug targets for Ebola virus disease
Vasudevan, Karthick; D, Thirumal Kumar; S, Udhaya Kumar; Saleem, Aisha; N, Nagasundaram; R, Siva; Tayubi, Iftikhar Aslam; Doss, C. George Priya; Zayed, Hatem... more authors ... less authors ( Elsevier , 2021 , Article)The World Health Organization declared Ebola virus disease(EVD) as the major outbreak in the 20th century. EVD was firstidentified in 1976 in South Sudan and the Democratic Republicof the Congo. EVD was transmitted from ... -
Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach.
S, Udhaya Kumar; Sankar, Srivarshini; Younes, Salma; D, Thirumal Kumar; Ahmad, Muneera Naseer; Okashah, Sarah Samer; Kamaraj, Balu; Al-Subaie, Abeer Mohammed; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( MDPI , 2020 , Article)Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved ... -
Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
P., Sneha; D., Thirumal Kumar; C., George Priya Doss; R., Siva; Zayed, Hatem ( Plos One , 2017 , Article)Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the ... -
An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia
S, Udhaya Kumar; D, Thirumal Kumar; R, Siva; C, George Priya Doss; Zayed, Hatem ( Elsevier , 2019 , Article)Type I galactosemia is a very rare autosomal recessive genetic metabolic disorder that occurs because of the mutations present in the galactose-1-phosphate uridyl transferase (GALT) gene, resulting in a deficiency of the ... -
An integrative bioinformatics pipeline to demonstrate the alteration of the interaction between the ALDH2*2 allele with NAD and Disulfiram.
J, Christy Priyadharshini; D, Thirumal Kumar; P, Sneha; R, Siva; W, Charles Emmanuel Jebaraj; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( Wiley , 2019 , Article)Alcohol use disorder (AUD) is a multifactorial psychiatric behavior disorder. Disulfiram is the first approved drug by the Food and Drug Administration for alcohol-dependent patients, which targets the ALDH2 enzyme. Several ... -
Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity
S, Udhaya Kumar; Rajan, Bithia; D, Thirumal Kumar; V, Anu Preethi; Abunada, Taghreed; Younes, Salma; Okashah, Sarah; Ethiraj, Selvarajan; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( MDPI , 2020 , Article)(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of premature heart attack, stroke, and death. To date, a key challenge has ... -
Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach
S, Udhaya Kumar; R, Bithia; D, Thirumal Kumar; Doss, C George Priya; Zayed, Hatem ( Taylor and Francis , 2020 , Article)K-Ras is a small GTPase and acts as a molecular switch by recruiting GEFs and GAPs, and alternates between the inert GDP-bound and the dynamic GTP-bound forms. The amino acid at position 12 of K-Ras is a hot spot for ... -
Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2.
P, Sneha; Ebrahimi, Elaheh Ahmad; Ghazala, Sara Ahmed; D, Thirumal Kumar; R, Siva; Priya Doss C, George; Zayed, Hatem... more authors ... less authors ( Wiley , 2018 , Article)Galactosemia type 2 is an autosomal recessive disorder characterized by the deficiency of galactokinase (GALK) enzyme due to missense mutations in GALK1 gene, which is associated with various manifestations such as hyper ...