تصفح حسب المؤلف "Al-Mansoob, Maryam"
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KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion
Al-Mansoob, Maryam; Gupta, Ishita; Stefan Rusyniak, Radoslaw; Ouhtit, Allal ( Blackwell Publishing Inc. , 2021 , Article Review)Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver. To unravel the ... -
Nano-Engineering in Traumatic Brain Injury
Al-Thani, Najlaa; Haider, Mohammad Z.; Al-Mansoob, Maryam; Patel, Stuti; Ahmad, Salma M.S.; Kobeissy, Firas; Shaito, Abdullah... more authors ... less authors ( Wiley , 2023 , Book chapter)Traumatic brain injury (TBI) is a leading cause of mortality and chronic disability worldwide TBI involves an initial primary phase triggered by an impactful force to the brain and a subsequent secondary pathological phase. ... -
PCF11, a Novel CD44-Downstream Transcriptional Target, Linking Its 3'-End Polyadenylation Function to Tumor Cell Metastasis
Al-Mansoob, Maryam; Ahmad, Salma M. S.; Ouhtit, Allal ( Frontiers Media S.A. , 2022 , Article Review)Breast Cancer (BC) is the most common and the major health issue in women worldwide. Metastasis, a multistep process, is the worst aspect of cancer and tumor cell invasion is the defining step. Tumor cell invasion requires ... -
Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
Shaito, Abdullah; Al-Mansoob, Maryam; Ahmad, Salma M S; Haider, Mohammad Z; Eid, Ali H; Posadino, Anna Maria; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Bentham Science Publisher , 2022 , Article Review)Neurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The ... -
SIRT1, a novel transcriptional downstream target of CD44, linking its deacetylase activity to tumor cell invasion/metastasis
Ahmad, Salma M. S.; Al-Mansoob, Maryam; Ouhtit, Allal ( Frontiers Media S.A. , 2022 , Short Survey)Our tetracycline-off-inducible CD44 expression system previously established in mouse model, revealed that activation of CD44 with its major ligand hyaluronan (HA) promoted breast cancer (BC) metastasis to the liver. To ... -
Validation of Novel Transcriptional Targets that Underpin CD44-promoted breast cancer cell invasion
Ahmad, Salma; Nazar, Hanan; Alatieh, Nouralhuda; Al-Mansoob, Maryam; Farooq, Zainab; Yusuf, Muna; Ouhtit, Allal... more authors ... less authors ( Qatar University Press , 2021 , Poster)Introduction: Breast cancer (BC) is the most common cancer worldwide, and metastasis is its worst aspect and the first cause of death. Metastasis is a multistep process, where an invasion is a recurring event. The process ...