Browsing by Author "Agouni, Abdelali"
Now showing items 21-40 of 52
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Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder
Dhulkifle, Hevna; Agouni, Abdelali; Zeidan, Asaad; Al-Kuwari, Mohammed Saif; Parray, Aijaz; Tolefat, Mohamed; Korashy, Hesham M.... more authors ... less authors ( MDPI , 2021 , Article Review)Autism spectrum disorder (ASD) is an umbrella term that includes many different disorders that affect the development, communication, and behavior of an individual. Prevalence of ASD has risen exponentially in the past ... -
Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development
Sayed, Tahseen S.; Maayah, Zaid H.; Zeidan, Heba A.; Agouni, Abdelali; Korashy, Hesham M. ( BioMed Central Ltd , 2022 , Article Review)The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several environmental pollutants. Decades of research have been carried out to understand the role of AhR as ... -
Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction
Osman, Aisha; Benameur, Tarek; Korashy, Hesham M.; Zeidan, Asad; Agouni, Abdelali ( MDPI , 2020 , Article)Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded protein response (UPR), aiming at ... -
Investigating the use of a lecture capture system within pharmacy education: Lessons from an internationally accredited undergraduate pharmacy program
Hussain, Farhat Naz; Al-Mannai, Reem; Diab, Mohammad Issam; Agouni, Abdelali ( Qatar University Press , 2020 , Poster)Introduction: Video lecture capture has been introduced to support students learning and assist with grasping difficult concepts. A variety of benefits is offered through the Echo360 system introduced at our institution ... -
Investigating the use of a lecture capture system within pharmacy education: Lessons from an undergraduate pharmacy program at Qatar University
Hussain, Farhat Naz; Al-Mannai, Reem; Diab, Mohammad Issam; Agouni, Abdelali ( Springer , 2020 , Article)© 2020, The Author(s). Video lecture capture is one of the most attractive e-tools that has been introduced to support students learning and assist with grasping difficult concepts. A variety of benefits is offered through ... -
Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells
Ola, El Atab; Ghantous, Crystal M.; El-Zein, Nabil; Farhat, Rima; Agouni, Abdelali; Korashy, Hesham M.; Djouhri, Laiche; Kamareddine, Layla; Zibara, Kazem; Zeidan, Asad... more authors ... less authors ( Elsevier , 2021 , Article)Hyperglycemia exerts various harmful effects on the vasculature. Studies have shown an association between the levels of the adipokines leptin and adiponectin (APN) and vascular complications in diabetes mellitus. The aim ... -
Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization
Nada, Khudair; Agouni, Abdelali; Elrayess, Mohamed A.; Najlah, Mohammad; Younes, Husam M.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier , 2020 , Article)Slurry-based Letrozole (LTZ)-loaded proniosomes were designed using sucrose or sorbitol as carriers and various ratios of cholesterol (CH) and Tween 80 (T80) as lipid composition. Proniosomes were hydrated and probe-sonicated ... -
Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players
Al-Muraikhy, Shamma; Sellami, Maha; Domling, Alexander S; Rizwana, Najeha; Agouni, Abdelali; Al-Khelaifi, Fatima; Donati, Francesco; Botre, Francesco; Diboun, Ilhame; Elrayess, Mohamed A... more authors ... less authors ( Frontiers Media , 2021 , Article)Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim ... -
The Metabolic Switch of Physical Activity in Non-Obese Insulin Resistant Individuals.
Almuraikhy, Shamma; Anwardeen, Najeha; Doudin, Asmma; Sellami, Maha; Domling, Alexander; Agouni, Abdelali; Al Thani, Asmaa A; Elrayess, Mohamed A... more authors ... less authors ( MDPI , 2023 , Article)Healthy non-obese insulin resistant (IR) individuals are at higher risk of metabolic syndrome. The metabolic signature of the increased risk was previously determined. Physical activity can lower the risk of insulin ... -
Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines.
Pasha, Mazhar; Sivaraman, Siveen K; Frantz, Ronald; Agouni, Abdelali; Munusamy, Shankar ( MDPI , 2019 , Article)Clear cell renal cell carcinoma (ccRCC) is the most common and lethal form of urological cancer diagnosed globally. Mutations of the von Hippel-Lindau tumor-suppressor gene and the resultant overexpression of hypoxia-inducible ... -
Microparticles as Potential Mediators of High Glucose-Induced Renal Cell Injury.
Ravindran, Sreenithya; Pasha, Mazhar; Agouni, Abdelali; Munusamy, Shankar ( MDPI , 2019 , Article)Diabetic nephropathy (DN) is the most common cause of chronic kidney disease worldwide. Activation of signaling pathways such as the mammalian target of rapamycin (mTOR), extracellular signal-regulated kinases (ERK), ... -
MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
Hourani, Shireen Bayan (2021 , Master Thesis)Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. Chemoresistance is attributed to the presence of long-lived cancer stem cells (CSCs) responsible for therapy failure. This study ... -
Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
Ghantous, Crystal M.; Farhat, Rima; Djouhri, Laiche; Alashmar, Sarah; Anlar, Gulsen; Korashy, Hesham M.; Agouni, Abdelali; Zeidan, Asad... more authors ... less authors ( hindawi , 2020 , Article)Hypertension induces vascular hypertrophy, which changes blood vessels structurally and functionally, leading to reduced tissue perfusion and further hypertension. It is also associated with dysregulated levels of the ... -
Molecular Mechanisms Underpinning Microparticle-Mediated Cellular Injury in Cardiovascular Complications Associated with Diabetes.
Benameur, Tarek; Osman, Aisha; Parray, Aijaz; Ait Hssain, Ali; Munusamy, Shankar; Agouni, Abdelali... more authors ... less authors ( Hindawi , 2019 , Article)Microparticles (MPs) are small vesicles shed from the cytoplasmic membrane of healthy, activated, or apoptotic cells. MPs are very heterogeneous in size (100-1,000 nm), and they harbor proteins and surface antigens specific ... -
Oral PTCTS (Particulated Transialidase) Removes Serum Microparticles and Decreases Inflammation in Atherosclerotic Plaques of Rabbits
Garavelo, Sherrira M.; Pereira, Jacqueline J.; Wadt, Nilsa S.Y.; Reis, Marcia M.; Ikegami, Renata N.; Kawakami, Joyce T.; Agouni, Abdelali; Palomino, Suely A.P.; Abdalla, Dulcineia; Higuchi, Maria de Lourdes... more authors ... less authors ( Scientific Research Publishing , 2015 , Article)Background: Previous studies showed that atherosclerotic plaque vulnerability was related with microparticles (MPs)-vesicles larger than 100 nm, which released MMP9 collagenase. In our pre- vious study, intramuscular ... -
Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fa/fa)
Agouni, Abdelali; Mostefai, Hadj Ahmed; Lagrue, Anne-Hélène; Sladkova, Martina; Rouet, Philippe; Desmoulin, Franck; Pechanova, Olga; Martínez, Maria Carmen; Andriantsitohaina, Ramaroson... more authors ... less authors ( Hindawi Publishing Corporation , 2017 , Article)The aim of this work was to study the vascular effects of dietary supplementation of a nonalcoholic red wine polyphenol extract, Provinols, in Zucker fatty (ZF) obese rats. ZF or lean rats received diet supplemented or not ... -
Predicting factors of public awareness and perception about the quality, safety of drinking water, and pollution incidents
Benameur, Tarek; Benameur, Nassima; Saidi, Neji; Tartag, Sakina; Sayad, Hadjer; Agouni, Abdelali... more authors ... less authors ( Springer , 2021 , Article)Public perception of drinking water quality and safety results from the interaction of multiple factors, including the public engagement, which requires sufficient knowledge and awareness. This issue has yet to be addressed ... -
Protein Tyrosine Phosphatase (PTP) 1B Inhibition Improves Endoplasmic Reticulum Stress-Induced Apoptosis and Impaired Angiogenic Response in Endothelial Cells
Abdelsalam, Shahenda Salaheldine; Agouni, Abdelali ( Qatar University Press , 2021 , Poster)Insulin is not only important for glucose homeostasis, but also plays a critical role in the activation of endothelial nitric oxide synthase (eNOS) to synthesize nitric oxide (NO) and keeping the endothelium functional. ... -
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress-impaired endothelial cell angiogenic response: A critical role for cell survival
ABDELSALAM, SHAHENDA S.; PASHA, MAZHAR; EL-GAMAL, HEBA; HASAN, MARAM; ELRAYESS, MOHAMED A.; ZEIDAN, ASAD; KORASHY, HESHAM M.; AGOUNI, ABDELALI... more authors ... less authors ( Spandidos publications , 2021 , Article)Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is ... -
Quantitative analysis of lecture-capture archive viewing by pharmacy students during the emergency switch to remote learning
Hussain, Farhat Naz; Al-Mannai, Reem; Agouni, Abdelali ( Qatar University Press , 2021 , Poster)Purpose: The COVID-19 pandemic caused the sudden suspension of face-to-face classes in many higher institutions worldwide. To leverage preparedness of higher education in similar emergencies preventing on-campus classes, ...