Browsing by Author "AlFarsi, Halema"
Now showing items 1-12 of 12
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Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype.
Allouch, Soumaya; Gupta, Ishita; Malik, Shaza; Al Farsi, Halema F; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2020 , Article)Breast and cervical cancers comprise 50% of all cancers during pregnancy. In particular, gestational breast cancer is considered one of the most aggressive types of cancers, which is a rare but fatal disease. However, the ... -
Circulating miRNAs in HER2-Positive and Triple Negative Breast Cancers: Potential Biomarkers and Therapeutic Targets.
Gupta, Ishita; Rizeq, Balsam; Vranic, Semir; Moustafa, Ala-Eddin Al; Al Farsi, Halema ( MDPI , 2020 , Article)Breast cancer is one of the most prevalent diseases among women worldwide and is highly associated with cancer-related mortality. Of the four major molecular subtypes, HER2-positive and triple-negative breast cancer (TNBC) ... -
Discovery of new therapeutic targets in ovarian cancer through identifying significantly non-mutated genes
Al-Farsi, Halema; Al-Azwani, Iman; Malek, Joel A.; Chouchane, Lotfi; Rafii, Arash; Halabi, Najeeb M.... more authors ... less authors ( BioMed Central Ltd , 2022 , Article)Background: Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are ... -
Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells
Fouzat, Arij; Hussein, Ola Jihad; Gupta, Ishita; Al-Farsi, Halema F.; Khalil, Ashraf; Al Moustafa, Ala Eddin... more authors ... less authors ( Frontiers Media , 2022 , Article)Elaeagnus angustifolia (EA) is used as an alternative medicine in the Middle East to manage numerous human diseases. We recently reported that EA flower extract inhibits cell proliferation and invasion of human oral and ... -
Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells
Jabeen, Ayesha; Sharma, Anju; Gupta, Ishita; Kheraldine, Hadeel; Vranic, Semir; Al Moustafa, Ala-Eddin; Al Farsi, Halema F... more authors ... less authors ( MDPI , 2020 , Article)Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ... -
Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.
Cyprian, Farhan S; Al-Farsi, Halema F; Vranic, Semir; Akhtar, Saghir; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, ... -
Gene expression and miRNAs profiling: Function and regulation in human epidermal growth factor receptor 2 (HER2) - positive breast cancer
Sareyeldin, Rasha M.; Gupta, Ishita; Al-Hashimi, Israa; Al-Thawadi, Hamda A.; Al Farsi, Halema F.; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI AG , 2019 , Article)Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 ... -
High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status.
Gupta, Ishita; Al Farsi, Halema; Jabeen, Ayesha; Skenderi, Faruk; Al-Thawadi, Hamda; AlAhmad, Yaman M; Al Moustafa, Ala-Eddin; Vranic, Semir... more authors ... less authors ( MDPI , 2020 , Article)Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes ... -
Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions.
Fernandes, Queenie; Allouch, Soumaya; Gupta, Ishita; Elmakaty, Ibrahim; Elzawawi, Khaled E; Amarah, Ahmed; Al-Thawadi, Hamda; Al-Farsi, Halema; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2022 , Article Review)The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered ... -
Incidence of HPVs, EBV and MMTV-like Virus in Breast Cancer in Qatar.
Gupta, Ishita; Al-Sarraf, Reem; Farghaly, Hanan; Vranic, Semir; Sultan, Ali A; Al-Thawadi, Hamda; Al Moustafa, Ala-Eddin; Al-Farsi, Halema F... more authors ... less authors ( Karger Publishers , 2022 , Article)Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these ... -
Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer.
Gupta, Ishita; Ulamec, Monika; Peric-Balja, Melita; Ramic, Snjezana; Al Moustafa, Ala-Eddin; Vranic, Semir; Al-Farsi, Halema F... more authors ... less authors ( Taylor and Francis , 2021 , Article)Breast cancer, the most frequent disease amongst women worldwide, accounts for the highest cancer-related mortality rate. Triple-negative breast cancer (TNBC) subtype encompasses ~15% of all breast cancers and lack estrogen, ... -
Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity.
Gupta, Ishita; Sareyeldin, Rasha M.; Al-Hashimi, Israa; Al-Thawadi, Hamda A.; Al Farsi, Halema; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2019 , Article)Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined ...