Browsing by Author "Brandão, Lucas André Cavalcanti"
Now showing items 1-6 of 6
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Hiv-1 infection transcriptomics: Meta-analysis of cd4+ t cells gene expression profiles
Coelho, Antonio Victor Campos; Gratton, Rossella; de Melo, João Paulo Britto; Andrade-Santos, José Leandro; Guimarães, Rafael Lima; Crovella, Sergio; Tricarico, Paola Maura; Brandão, Lucas André Cavalcanti... more authors ... less authors ( MDPI , 2021 , Article Review)HIV-1 infection elicits a complex dynamic of the expression various host genes. High throughput sequencing added an expressive amount of information regarding HIV-1 infections and pathogenesis. RNA sequencing (RNA-Seq) is ... -
In silico analysis of molecular interactions between HIV-1 glycoprotein gp120 and TNF receptors
Neyla Maria Pereira, Alves; de Moura, Ronald Rodrigues; Bernardo, Lucas Coêlho; Agrelli, Almerinda; de Oliveira, Ana Sofia Lima Estevão; da Silva, Natália Pereira; Crovella, Sergio; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Elsevier , 2021 , Article)Proinflammatory microenvironmental is crucial for the Human Immunodeficiency Virus Type 1 (HIV-1) pathogenesis. The viral glycoprotein 120 (gp120) must interact with the CD4+ T cell chemokine receptor (CCR5) and a co-receptor ... -
A loss-of-function NCSTN mutation associated with familial Dowling Degos disease and hidradenitis suppurativa
de Oliveira, Ana Sofia Lima Estevao; de Siqueira, Roberta Cardoso; Nait-Meddour, Cécile; Tricarico, Paola Maura; Moura, Ronald; Agrelli, Almerinda; d'Adamo, Adamo Pio; Jamain, Stéphane; Crovella, Sergio; de Fátima Medeiros Brito, Maria; Boniotto, Michele; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Wiley , 2023 , Article)Dowling Degos disease (DDD) is a rare autosomal dominant genodermatosis characterized by acquired, slowly progressive reticulated pigmented lesions primarily involving flexural skin areas. Mutations in KRT5, POGLUT-1 and ... -
Multiomics integration in skin diseases with alterations in notch signaling pathway: PlatOMICs phase 1 deployment
Brandão, Lucas André Cavalcanti; Tricarico, Paola Maura; Gratton, Rossella; Agrelli, Almerinda; Zupin, Luisa; Abou-Saleh, Haissam; Moura, Ronald; Crovella, Sergio... more authors ... less authors ( MDPI , 2021 , Article Review)The high volume of information produced in the age of omics was and still is an important step to understanding several pathological processes, providing the enlightenment of complex molecular networks and the identification ... -
An overview of Zika virus genotypes and their infectivity
Bernardo-Menezes, Lucas Coêlho; Agrelli, Almerinda; de Oliveira, Ana Sofia Lima Estevão; de Moura, Ronald Rodrigues; Crovella, Sergio; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Sociedade Brasileira de Medicina Tropical , 2022 , Article Review)Zika virus (ZIKV) is an enveloped, single-stranded RNA arbovirus belonging to the genus Flavivirus. It was first isolated from a sentinel monkey in Uganda in 1947. More recently, ZIKV has undergone rapid geographic expansion ... -
Variant Enrichment Analysis to Explore Pathways Functionality in Complex Autoinflammatory Skin Disorders through Whole Exome Sequencing Analysis.
Brandão, Lucas André Cavalcanti; Moura, Ronald Rodrigues de; Marzano, Angelo Valerio; Moltrasio, Chiara; Tricarico, Paola Maura; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article)The challenge of unravelling the molecular basis of multifactorial disorders nowadays cannot rely just on association studies searching for potential causative variants shared by groups of patients and not present in healthy ...