Browsing by Author "Ghanem, Simona S"
Now showing items 1-2 of 2
-
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
Ardah, Mustafa T; Ghanem, Simona S; Abdulla, Sara A; Lv, Guohua; Emara, Mohamed M; Paleologou, Katerina E; Vaikath, Nishant N; Lu, Jia-Hong; Li, Min; Vekrellis, Konstantinos; Eliezer, David; El-Agnaf, Omar M A... more authors ... less authors ( BMC , 2020 , Article)Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson's disease (PD), multiple system atrophy, and dementia ... -
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
Hmila, Issam; Vaikath, Nishant N; Majbour, Nour K; Erskine, Daniel; Sudhakaran, Indulekha P; Gupta, Vijay; Ghanem, Simona S; Islam, Zeyaul; Emara, Mohamed M; Abdesselem, Houari B; Kolatkar, Prasanna R; Achappa, Devaya K; Vinardell, Tatiana; El-Agnaf, Omar M A... more authors ... less authors ( FEBS PRESS , 2022 , Article)Nanobodies (Nbs), the single-domain antigen-binding fragments of dromedary heavy-chain antibodies (HCAb), are excellent candidates as therapeutic and diagnostic tools in synucleinopathies because of their small size, ...