Browsing by Author "Al Moustafa, Ala-Eddin"
Now showing items 21-40 of 81
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Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer
Elkhalifa, Dana; Siddique, Abu Bakar; Qusa, Mohammed; Cyprian, Farhan S.; El Sayed, Khalid; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf... more authors ... less authors ( Elsevier Masson s.r.l. , 2020 , Article)Great strides have been made in triple negative breast cancer (TNBC) treatment, which represents 20% of total predicted annual US breast cancer (BC) cases. Despite the development of several therapeutics, TNBC patients ... -
Development of oral cancer: Risk factors and prevention strategies
Al Moustafa, Ala Eddin ( Springer International Publishing , 2017 , Book)This book aims to provide the reader with a complete understanding of the development of oral cancer by explaining the role of a wide variety of implicated risk factors and identifying their gene targets and key regulators. ... -
Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model
Zakaria, Zain Z; Mahmoud, Nouf N; Benslimane, Fatiha M; Yalcin, Huseyin C.; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( American Chemical Society , 2022 , Article)Background: nanotechnology is one of the fastest-growing areas, and it is expected to have a substantial economic and social impact in the upcoming years. Gold particles (AuNPs) offer an opportunity for wide-ranging ... -
DNA Damage/Repair Management in Cancers
Alhmoud, Jehad F; Woolley, John F; Al Moustafa, Ala-Eddin; Malki, Mohammed Imad ( MDPI , 2020 , Article Review)DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand. When DNA ... -
DNA Damage/Repair Management in Cancers
Alhmoud, Jehad F.; Woolley, John F.; Al Moustafa, Ala-Eddin; Malki, Mohammed Imad ( Routledge , 2021 , Book chapter)DNA damage can alter nucleotide sequences and lead to expression of dysfunctional proteins that impact normal cellular physiology. Sources of DNA damage can be endogenous or exogenous and include reactive oxygen species ... -
E-cadherin/catenin complex modulations in human oral cancer
Al Moustafa, Ala Eddin; Yasmeen, Amber ( Springer Netherlands , 2015 , Book chapter)Oral cancer is a common neoplasm in both male and female worldwide; the incidence and mortality of this cancer have increased over the past decades. Cancer metastasis is a major cause of morbidity and mortality in oral ... -
E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis.
Ashour, Anas; Alhussain, Hashim; Rashid, Umar Bin; Abughazzah, Labiba; Gupta, Ishita; Malki, Ahmed; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2020 , Article)E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a "healthy method" of tobacco consumption. The adverse outcomes of ECS on the respiratory and cardiovascular ... -
E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation
Al Moustafa, Ala-Eddin ( Taylor & Francis , 2015 , Article)It is estimated that 10–20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, ... -
Editorial: EBV-Associated Carcinomas: Presence, Role, and Prevention Strategies.
Al Moustafa, Ala-Eddin; Ahmed, Hussain G; Wulf, Gerburg; Sultan, Ali A ( Frontiers Media , 2019 , Other)This special issue addresses an important topic related to the role of Epstein-Barr virus (EBV) in human carcinomas initiation and progression, which is one of the most common viral infections worldwide. Today, the ... -
Effect of Water-Pipe Smoking on the Normal Development of Zebrafish
Zakaria, Zain Zaki; Aladwi, Shaima Ahmad; Benslimane, Fatiha; Al-Absi, Enas S.; Al-Shafai, Mashael; Yalcin, Huseyin C.; Khalil, Ashraf; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( MDPI , 2021 , Article)Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully ... -
Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells
Fouzat, Arij; Hussein, Ola Jihad; Gupta, Ishita; Al-Farsi, Halema F.; Khalil, Ashraf; Al Moustafa, Ala Eddin... more authors ... less authors ( Frontiers Media , 2022 , Article)Elaeagnus angustifolia (EA) is used as an alternative medicine in the Middle East to manage numerous human diseases. We recently reported that EA flower extract inhibits cell proliferation and invasion of human oral and ... -
Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells
Jabeen, Ayesha; Sharma, Anju; Gupta, Ishita; Kheraldine, Hadeel; Vranic, Semir; Al Moustafa, Ala-Eddin; Al Farsi, Halema F... more authors ... less authors ( MDPI , 2020 , Article)Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ... -
Elaeagnus Angustifolia: a Promising Medicinal Plant for Cancer Theraby
Mohamed, Islam; Moahmed, Ahmed; Abdelkader, Mennatallah; Saleh, Alaaeldin; Al-Moustafa, Ala-Eddin ( Qatar University Press , 2020 , Poster)Introduction: Elaeagnus angustifolia (EA) is a medicinal plant that has been used for centuries in treating many human diseases, in the Middle East, including fever, amoebic dysentery, gastrointestinal problems. However, ... -
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential
Kheraldine, Hadeel; Rachid, Ousama; M Habib, Abdella; Al Moustafa, Ala-Eddin; F. Benter, Ibrahim ( Elsevier , 2021 , Article)Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level. However, emerging ... -
Epstein-Barr virus (EBV) status in colorectal cancer: a mini review
Bedri, Shahinaz; Sultan, Ali A; Alkhalaf, Moussa; Al Moustafa, Ala-Eddin; Vranic, Semir ( Taylor & Francis , 2018 , Article)Epstein-Barr virus (EBV) is a well-characterized oncovirus, associated with several malignancies. The complex and heterogeneous nature of colorectal cancer (CRC) has led to many epidemiological causal associations with ... -
Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.
Cyprian, Farhan S; Al-Farsi, Halema F; Vranic, Semir; Akhtar, Saghir; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, ... -
Epstein-Barr virus and its association with Fascin expression in colorectal cancers in the Syrian population: A tissue microarray study.
Al-Antary, Noor; Farghaly, Hanan; Aboulkassim, Tahar; Yasmeen, Amber; Akil, Nizar; Al Moustafa, Ala-Eddin... more authors ... less authors ( Taylor & Francis , 2017 , Article)Colorectal cancer (CRC) is the third most common malignancy in both men and women worldwide. Colorectal carcinogenesis is a complex, multistep process involving environmental and lifestyle features as well as sequential ... -
Epstein-Barr Virus in Gliomas: Cause, Association, or Artifact?
Akhtar, Saghir; Vranic, Semir; Cyprian, Farhan Sachal; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Gliomas are the most common malignant brain tumors and account for around 60% of all primary central nervous system cancers. Glioblastoma multiforme (GBM) is a grade IV glioma associated with a poor outcome despite recent ... -
Fascin in Gynecological Cancers: An Update of the Literature
Gupta, Ishita; Vranic, Semir; Al-Thawadi, Hamda; Al Moustafa, Ala-Eddin ( MDPI , 2021 , Article)Fascin is an actin-binding protein that is encoded by the gene (located on chromosome 7). It triggers membrane projections and stimulates cell motility in cancer cells. Fascin overexpression has been described in different ... -
Gene expression and miRNAs profiling: Function and regulation in human epidermal growth factor receptor 2 (HER2) - positive breast cancer
Sareyeldin, Rasha M.; Gupta, Ishita; Al-Hashimi, Israa; Al-Thawadi, Hamda A.; Al Farsi, Halema F.; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI AG , 2019 , Article)Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 ...