Browsing by Author "Sandrin-Garcia, Paula"
Now showing items 1-7 of 7
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Can Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity?
Guaraná, Werbson Lima; Lima, Camilla Albertina Dantas; Barbosa, Alexandre Domingues; Crovella, Sergio; Sandrin-Garcia, Paula ( MDPI , 2022 , Article)The immune system plays a critical role in bone homeostasis and, consequently, in the pathophysiology of postmenopausal osteoporosis (OP) since estrogen deficiency induces the inflammasome and increases production of ... -
CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study
Lima, Suelen Cristina; Gomes da Silva, Isaura Isabelle Fonseca; Nascimento, Denise de Queiroga; de Moura, Ronald Rodrigues; Mesquita, Matheus da Silva; Asano, Nadja Maria Jorge; Fernandes, Gisele Vagjel; Valente, Lucila Maria; Rushansky, Eliezer; Mariano, Maria Helena Queiroz de Araújo; Xavier, Ricardo Machado; Chies, José Artur Bogo; Crovella, Sergio; Sandrin-Garcia, Paula... more authors ... less authors ( Wiley , 2021 , Other)Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are influenced by genetic variants in immune system HLA genes. The Class II Major Histocompatibility Complex Transactivator (CIITA) is an important co-activator ... -
Differential distribution of vitamin D receptor (VDR) gene variants and its expression in systemic lupus erythematosus
De Azevêdo Silva, Jaqueline; de Lima, Suelen Cristina; Fragoso, Thiago Sotero; Cavalcanti, Catarina Addobbati Jordão; Barbosa, Alexandre Domingues; Borborema, Maria Eduarda de Albuquerque; de Lucena, Thays Maria Costa; Duarte, Angela Luzia Branco Pinto; Crovella, Sergio; Sandrin-Garcia, Paula... more authors ... less authors ( Wiley , 2022 , Article)Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder that displays an important genetic background. Vitamin D3 (VD3) through its receptor (VDR) plays an important immunomodulatory role in autoimmune ... -
Expression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE)
Nascimento, Denise de Queiroga; da Silva, Isaura Isabelle Fonseca Gomes; Lima, Camilla Albertina Dantas; Cavalcanti, André de Souza; Roberti, Luciana Rodrigues; Queiroz, Rosane Gomes de Paula; Ferriani, Virginia Paes Leme; Crovella, Sergio; Carvalho, Luciana Martins de; Sandrin-Garcia, Paula... more authors ... less authors ( Taylor and Francis , 2022 , Article)Childhood- onset systemic lupus erythematosus (cSLE) is a multisystem inflammatory disease that can lead to severe clinical conditions resulting in early comorbidities. Several genetic, environmental, and immunological ... -
Full-house nephropathy associated with high expression of SPATA5L1 due to a genetic pathogenic variant
De Carvalho, Luciana Martins; De Sousa, Graziella Ribeiro; Moura, Ronald; Saggioro, Fabiano; Facincani, Inalda; Costa, Roberto; Kahwage, Paola Pinheiro; De Paula Queiroz, Rosane Gomes; Valera, Elvis Terci; Crovella, Sergio; Sandrin-Garcia, Paula... more authors ... less authors ( Oxford University Press , 2022 , Article)DEAR EDITOR, Non-lupus full-house nephropathy is a diagnostic challenge of yet unknown aetiology that does not satisfy criteria for SLE classification . Spermatogenesis-associated protein 5-like protein 1 (SPATA5L1) is ... -
MYD88, IRAK3 and Rheumatoid Arthritis pathogenesis: Analysis of differential gene expression in CD14 + monocytes and the inflammatory cytokine levels.
Gomes da Silva, Isaura Isabelle Fonseca; Barbosa, Alexandre Domingues; Souto, Fabricio Oliveira; Maia, Maria de Mascena Diniz; Crovella, Sergio; Souza, Paulo Roberto Eleuterio de; Sandrin-Garcia, Paula... more authors ... less authors ( Elsevier , 2021 , Article)Rheumatoid arthritis (RA) is a well-known chronic inflammatory disorder. Two molecular players act in the inflammation balance of the disease: MyD88 (Myeloid differentiation primary response 88) is related to TLR (Toll-like ... -
Vitamin D receptor gene polymorphisms influence on clinical profile and bone mineral density at different skeletal sites in postmenopausal osteoporotic women.
de Azevêdo Silva, Jaqueline; de Lima, Camilla Albertina Dantas; Guaraná, Werbson Lima; Barbosa, Alexandre Domingues; Fragoso, Thiago Sotero; Duarte, Ângela Luzia Branco Pinto; Crovella, Sergio; Sandrin-Garcia, Paula... more authors ... less authors ( Wiley , 2023 , Article)Bone remodeling is marked by bone synthesis and absorption balance, and any altered dynamic in this process leads to osteoporosis (OP). The interaction of hormonal, environmental and genetic factors regulate bone metabolism. ...