Browsing by Author "Aragam, Krishna G."
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Association of Habitual Alcohol Intake with Risk of Cardiovascular Disease
Biddinger, Kiran J.; Emdin, Connor A.; Haas, Mary E.; Wang, Minxian; Hindy, George; Ellinor, Patrick T.; Kathiresan, Sekar; Khera, Amit V.; Aragam, Krishna G.... more authors ... less authors ( American Medical Association , 2022 , Article)Importance: Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible ... -
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Aragam, Krishna G.; Jiang, Tao; Goel, Anuj; Kanoni, Stavroula; Wolford, Brooke N.; Atri, Deepak S.; Weeks, Elle M.; Wang, Minxian; Hindy, George; Zhou, Wei; Grace, Christopher; Roselli, Carolina; Marston, Nicholas A.; Kamanu, Frederick K.; Surakka, Ida; Venegas, Loreto Muñoz; Sherliker, Paul; Koyama, Satoshi; Ishigaki, Kazuyoshi; svold, Bjørn O.; Brown, Michael R.; Brumpton, Ben; de Vries, Paul S.; Giannakopoulou, Olga; Giardoglou, Panagiota; Gudbjartsson, Daniel F.; Güldener, Ulrich; Haider, Syed M. Ijlal; Helgadottir, Anna; Ibrahim, Maysson; Kastrati, Adnan; Kessler, Thorsten; Kyriakou, Theodosios; Konopka, Tomasz; Li, Ling; Ma, Lijiang; Meitinger, Thomas; Mucha, Sören; Munz, Matthias; Murgia, Federico; Nielsen, Jonas B.; Nöthen, Markus M.; Pang, Shichao; Reinberger, Tobias; Schnitzler, Gavin; Smedley, Damian; Thorleifsson, Gudmar; von Scheidt, Moritz; Ulirsch, Jacob C.; Danesh, John; Arnar, David O.; Burtt, Noël P.; Costanzo, Maria C.; Flannick, Jason; Ito, Kaoru; Jang, Dong-Keun; Kamatani, Yoichiro; Khera, Amit V.; Komuro, Issei; Kullo, Iftikhar J.; Lotta, Luca A.; Nelson, Christopher P.; Roberts, Robert; Thorgeirsson, Gudmundur; Thorsteinsdottir, Unnur; Webb, Thomas R.; Baras, Aris; Björkegren, Johan L. M.; Boerwinkle, Eric; Dedoussis, George; Holm, Hilma; Hveem, Kristian; Melander, Olle; Morrison, Alanna C.; Orho-Melander, Marju; Rallidis, Loukianos S.; Ruusalepp, Arno; Sabatine, Marc S.; Stefansson, Kari; Zalloua, Pierre; Ellinor, Patrick T.; Farrall, Martin; Danesh, John; Ruff, Christian T.; Finucane, Hilary K.; Hopewell, Jemma C.; Clarke, Robert; Gupta, Rajat M.; Erdmann, Jeanette; Samani, Nilesh J.; Schunkert, Heribert; Watkins, Hugh; Willer, Cristen J.; Deloukas, Panos; Kathiresan, Sekar; Butterworth, Adam S.; de Vries, Paul S.; von Scheidt, Moritz... more authors ... less authors ( Nature Research , 2022 , Article)The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ... -
Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease
Hindy, George; Aragam, Krishna G.; Ng, Kenney; Chaffin, Mark; Lotta, Luca A.; Baras, Aris; Drake, Isabel; Orho-Melander, Marju; Melander, Olle; Kathiresan, Sekar; Khera, Amit V.... more authors ... less authors ( American Heart Association , 2020 , Article)OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ... -
Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease.
Fahed, Akl C; Aragam, Krishna G; Hindy, George; Chen, Yii-Der Ida; Chaudhary, Kumardeep; Dobbyn, Amanda; Krumholz, Harlan M; Sheu, Wayne H H; Rich, Stephen S; Rotter, Jerome I; Chowdhury, Rajiv; Cho, Judy; Do, Ron; Ellinor, Patrick T; Kathiresan, Sekar; Khera, Amit V... more authors ... less authors ( American Heart Association , 2020 , Article)N/A