Browsing by Author "Rafii, Arash"
Now showing items 1-5 of 5
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Discovery of new therapeutic targets in ovarian cancer through identifying significantly non-mutated genes
Al-Farsi, Halema; Al-Azwani, Iman; Malek, Joel A.; Chouchane, Lotfi; Rafii, Arash; Halabi, Najeeb M.... more authors ... less authors ( BioMed Central Ltd , 2022 , Article)Background: Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are ... -
Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review
Chamseddine, Reem S.; Wahbeh, Farah; Chervenak, Frank; Salomon, Laurent J.; Ahmed, Baderledeen; Rafii, Arash... more authors ... less authors ( Hindawi , 2020 , Article)With the emergence of SARS-CoV-2 and its rapid spread, concerns regarding its effects on pregnancy outcomes have been growing. We reviewed 245 pregnancies complicated by maternal SARS-CoV-2 infection across 48 studies ... -
Signal transducer and activator of transcription 3 (Stat3) suppresses stat1/interferon signaling pathway and inflammation in senescent preadipocytes
Madani, Aisha Y.; Majeed, Yasser; Abdesselem, Houari B.; Agha, Maha V.; Vakayil, Muneera; Al Sukhun, Nour K.; Halabi, Najeeb M.; Kumar, Pankaj; Hayat, Shahina; Elrayess, Mohamed A.; Rafii, Arash; Suhre, Karsten; Mazloum, Nayef A.... more authors ... less authors ( MDPI , 2021 , Article)© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT ... -
Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes.
Madani, Aisha Y; Majeed, Yasser; Abdesselem, Houari B; Agha, Maha V; Vakayil, Muneera; Sukhun, Nour K Al; Halabi, Najeeb M; Kumar, Pankaj; Hayat, Shahina; Elrayess, Mohamed A; Rafii, Arash; Suhre, Karsten; Mazloum, Nayef A... more authors ... less authors ( MDPI , 2021 , Article)Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT has been linked to inflammation, insulin-resistance (IR), ... -
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways.
Majeed, Yasser; Halabi, Najeeb; Madani, Aisha Y; Engelke, Rudolf; Bhagwat, Aditya M; Abdesselem, Houari; Agha, Maha V; Vakayil, Muneera; Courjaret, Raphael; Goswami, Neha; Hamidane, Hisham Ben; Elrayess, Mohamed A; Rafii, Arash; Graumann, Johannes; Schmidt, Frank; Mazloum, Nayef A... more authors ... less authors ( Nature Research , 2021 , Article)The NAD-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or NAD boosters alleviate metabolic complications. ...