Browsing by Author "Pineyro, Graciela"
Now showing items 1-4 of 4
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Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation
Mansour, Ahmed; Nagi, Karim; Dallaire, Paul; Lukasheva, Viktoriya; Le Gouill, Christian; Bouvier, Michel; Pineyro, Graciela... more authors ... less authors ( American Chemical Society , 2021 , Article)Prolonged exposure to opioid receptor agonists triggers adaptations in the adenylyl cyclase (AC) pathway that lead to enhanced production of cyclic adenosine monophosphate (cAMP) upon withdrawal. This cellular phenomenon ... -
Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.
Benredjem, Besma; Gallion, Jonathan; Pelletier, Dennis; Dallaire, Paul; Charbonneau, Johanie; Cawkill, Darren; Nagi, Karim; Gosink, Mark; Lukasheva, Viktoryia; Jenkinson, Stephen; Ren, Yong; Somps, Christopher; Murat, Brigitte; Van Der Westhuizen, Emma; Le Gouill, Christian; Lichtarge, Olivier; Schmidt, Anne; Bouvier, Michel; Pineyro, Graciela... more authors ... less authors ( Springer Nature , 2019 , Article)Signaling diversity of G protein-coupled (GPCR) ligands provides novel opportunities to develop more effective, better-tolerated therapeutics. Taking advantage of these opportunities requires identifying which effectors ... -
Molecular aspects of delta opioid receptors.
Gendron, Louis; Nagi, Karim; Zeghal, Manel; Giguère, Patrick M; Pineyro, Graciela ( Elsevier , 2019 , Article)The delta opioid receptor (DOP) belongs to the Class A, rhodopsin-like family of G protein-coupled receptors. Although this receptor has a high level of similarity with the other opioid receptors, it displays unique aspects ... -
Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias.
Pineyro, Graciela; Nagi, Karim ( Elsevier , 2020 , Article)Opioid analgesics are elective for treating moderate to severe pain but their use is restricted by severe side effects. Signaling bias has been proposed as a viable means for improving this situation. To exploit this ...