Browsing by Author "n 2012188827"
Now showing items 1-4 of 4
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Bio-vehicles of cytotoxic drugs for delivery to tumor specific targets for cancer precision therapy
Layla, Al-mansoori; Elsinga, Philip; Goda, Sayed K. ( Elsevier , 2021 , Article Review)Abnormal structural and molecular changes in malignant tissues were thoroughly investigated and utilized to target tumor cells, hence rescuing normal healthy tissues and lowering the unwanted side effects as non-specific ... -
In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy
Al-Mansoori, Layla; Bashraheel, Sara S; Qahtani, Alanod D Al; O'Connor, C David; Elsinga, Philip; Goda, Sayed K... more authors ... less authors ( Impact Journals , 2020 , Article)The sequence asparagine-glycine arginine (NGR), flanked by Cysteine (Cys) residues so as to form a disulfide-bridge (CNGRC), has previously been found to target and bind specifically to aminopeptidase N (APN), which is ... -
Production of active long lasting CNGRC-CPG2 fusion protein using PEGylation to be used in Ligand Directed Cancer Therapy
Al-Mansoori, Layla Jedea; Elsinga, Philip; Goda, Sayed ( Qatar University Press , 2020 , Poster)Aminopeptidase N (APN) is one of the important enzymes highly expressed in metastatic cancers, thus employed as a marker to target tumor cells. CPG2-CNGRC fusion protein is produced to target high APN expressing cancer ... -
Production of Long-Acting CNGRC–CPG2 Fusion Proteins: New Derivatives to Overcome Drug Immunogenicity of Ligand-Directed Enzyme Prodrug Therapy for Targeted Cancer Treatment
Al-Mansoori, Layla; Al Qahtani, Alanod D.; Elsinga, Philip; Goda, Sayed K. ( SAGE , 2021 , Article)Objectives: Aminopeptidase N (APN) is an enzyme highly expressed in metastatic cancers and could be used in targeted cancer therapy. Our previous work showed the successful construction of CNGRC–carboxypeptidase G2 (CPG2) ...