Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients
التاريخ
2016-09-15المؤلف
Myronovkij, SeverynNegrych, Nazar
Nehrych, Tetyana
Tkachenko, Volodymyr
Souchelnytskyi, Serhiy
Stoika, Rostyslav
Kit, Yuriy
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
Monitoring of multiple sclerosis (MS) requires additional molecular markers. Recently, we used original TCA-precipitation/extraction approach in combination with MALDI TOF/TOF mass-spectrometry and identified earlier unknown 48 kDa form of the unconventional myosin IC isoform b (Myo1C) in blood serum of the MS patients. Further examination of TCA-extracted fraction of blood serum of these patients by means of thin-layer chromatography and HPLC gel-filtration allowed detecting 300-500 Da peptides. MALDI TOF/TOF massspectrometry of these peptides showed that they contain Ser-Pro-Cys amino acid sequence. We discussed potential mechanisms of a release of these peptides that were earlier unknown in blood serum of the MS patients.
DOI/handle
http://hdl.handle.net/10576/11317المجموعات
- أبحاث الطب [1314 items ]
وثائق ذات صلة
عرض الوثائق المتصلة بواسطة: العنوان، المؤلف، المنشئ والموضوع.
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