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AuthorAugustine, Robin
AuthorZahid, Alap
AuthorWang, Mian
AuthorWebster, Thomas j.
AuthorHasan, Anwarul
Available date2020-05-14T09:55:42Z
Publication Date2019
Publication NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ResourceScopus
ISSN1557170X
URIhttp://dx.doi.org/10.1109/EMBC.2019.8857111
URIhttp://hdl.handle.net/10576/14799
AbstractTissue engineering is the use of a combination of cells, biomaterials and appropriate signals to repair or improve the functions of damaged tissues. Our group is exploiting various approaches to effectively encapsulate multiple growth factors in polymeric scaffolds for tissue engineering and wound healing applications. In this report, some of the exciting results from our most recent and ongoing projects are outlined with a focus on the use of connective tissue growth factor (CTGF). CTGF is a secreted protein with major roles in angiogenesis, chondrogenesis, osteogenesis and tissue repair. CTGF can play a major role in tissue regeneration by enhancing cell proliferation and promoting cell migration. CTGF was incorporated to electrospun polymeric fibers to provide sustained release. Experimental results demonstrated the ability of scaffolds incorporated with CTGF to promote cell proliferation and cell migration. This study shows the application potential of the developed scaffolds in various tissue engineering applications. - 2019 IEEE.
Languageen
PublisherInstitute of Electrical and Electronics Engineers Inc.
SubjectConnective Tissue Growth Factor
Fibrosis
Matricellular protein
TitleGrowth factor releasing core-shell polymeric scaffolds for tissue engineering applications
TypeConference Paper
Pagination1066-1069
dc.accessType Abstract Only


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