Improved liquid phase separation processes for generating biodegradable microspheres loaded with high concentrations of drugs for tumor embolization
Author | Lu, Shoutao |
Author | Jun, Zhang |
Author | Li, Maoquan |
Author | Hou, Wenbo |
Author | Yin, Yuxia |
Author | Zhou, Chao |
Author | Liu, Guang |
Author | Duan, Cuihai |
Author | Toft, Egon Steen |
Author | Zhang, Haijun |
Available date | 2020-08-18T08:34:46Z |
Publication Date | 2019 |
Publication Name | Polymer-Plastics Technology and Materials |
Resource | Scopus |
ISSN | 25740881 |
Abstract | Drug-eluting microspheres are the most commonly used particulate embolic agents for transarterial chemoembolization of liver tumors. However, drug loading of degradable embolic particles is often insufficient. In the current study, microspheres prepared from poly(D,L-lactic-co-glycolic acid) were investigated as a biodegradable embolic agent for arterial embolization applications. Through modified solvent evaporation and liquid-induced phase separation, high drug loading (as high as 32%) and low solvent residue (as low as 0.03%) was achieved. Degradation performance,1H NMR, and the nonsolvent's influence on solvent residue content were assessed. These drug-loading microspheres with biodegradability hold promise for embolization therapies. 50. - 2018 Taylor & Francis Group, LLC. |
Sponsor | This work was supported by NSFC (Grant No. 81771417), and National Science & Technology Pillar Program(Grant No. 2012BAI15B06) |
Language | en |
Publisher | Taylor and Francis Inc. |
Subject | Degradable Embolization Microsphere Sustained release |
Type | Article |
Pagination | 1005-1012 |
Issue Number | 9 |
Volume Number | 58 |
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Medicine Research [1470 items ]