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AuthorBhat, Ajaz A
AuthorSyed, Najeeb
AuthorTherachiyil, Lubna
AuthorNisar, Sabah
AuthorHashem, Sheema
AuthorMacha, Muzafar A
AuthorYadav, Santosh K
AuthorKrishnankutty, Roopesh
AuthorMuralitharan, Shanmugakonar
AuthorAl-Naemi, Hamda
AuthorBagga, Puneet
AuthorReddy, Ravinder
AuthorDhawan, Punita
AuthorAkobeng, Anthony
AuthorUddin, Shahab
AuthorFrenneaux, Michael P
AuthorEl-Rifai, Wael
AuthorHaris, Mohammad
Available date2020-09-14T08:25:46Z
Publication Date2020-01-01
Publication NameInternational Journal of Molecular Sciences
Identifierhttp://dx.doi.org10.3390/ijms21020569
CitationBhat AA, Syed N, Therachiyil L, et al. Claudin-1, A Double-Edged Sword in Cancer. Int J Mol Sci. 2020;21(2):569. Published 2020 Jan 15. doi:10.3390/ijms21020569
ISSN1661-6596
URIhttp://hdl.handle.net/10576/16101
AbstractClaudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated and studied in a multitude of diseases. Claudins not only regulate paracellular transepithelial/transendothelial transport but are also critical for cell growth and differentiation. Not only tissue-specific but the differential expression in malignant tumors is also the focus of claudin-related research. In addition to up- or down-regulation, claudin proteins also undergo delocalization, which plays a vital role in tumor invasion and aggressiveness. Claudin (CLDN)-1 is the most-studied claudin in cancers and to date, its role as either a tumor promoter or suppressor (or both) is not established. In some cancers, lower expression of CLDN-1 is shown to be associated with cancer progression and invasion, while in others, loss of CLDN-1 improves the patient survival. Another topic of discussion regarding the significance of CLDN-1 is its localization (nuclear or cytoplasmic vs perijunctional) in diseased states. This article reviews the evidence regarding CLDN-1 in cancers either as a tumor promoter or suppressor from the literature and we also review the literature regarding the pattern of CLDN-1 distribution in different cancers, focusing on whether this localization is associated with tumor aggressiveness. Furthermore, we utilized expression data from The Cancer Genome Atlas (TCGA) to investigate the association between CLDN-1 expression and overall survival (OS) in different cancer types. We also used TCGA data to compare CLDN-1 expression in normal and tumor tissues. Additionally, a pathway interaction analysis was performed to investigate the interaction of CLDN-1 with other proteins and as a future therapeutic target.
Languageen
PublisherMDPI
Subjectclaudin 1
epithelial to mesenchymal transition
metastasis
tight junctions
tumor
TitleClaudin-1, A Double-Edged Sword in Cancer.
TypeArticle Review
Issue Number2
Volume Number21
ESSN1422-0067
dc.accessType Open Access


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