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AuthorBertok, Tomas
AuthorDosekova, Erika
AuthorHolazova, Alena
AuthorLorencova, Lenka
AuthorKasak, Peter
AuthorTkac, Jan
Available date2020-11-26T10:24:09Z
Publication Date2017
Publication NameMicrochimica Acta
ResourceScopus
ISSN263672
URIhttp://dx.doi.org/10.1007/s00604-017-2410-1
URIhttp://hdl.handle.net/10576/17075
AbstractScreening serum for the presence of prostate specific antigen (PSA) belongs to the most common approach for the detection of prostate cancer. This review (with 156 refs.) addresses recent developments in PSA detection based on the use of various kinds of nanomaterials. It starts with an introduction into the field, the significance of testing for PSA, and on current limitations. A first main section treats electrochemical biosensors for PSA, with subsections on methods based on the use of gold electrodes, graphene or graphene-oxide, carbon nanotubes, hybrid nanoparticles, and other types of nanoparticles. It also covers electrochemical methods based on the enzyme-like activity of PSA, on DNA-, aptamer- and biofuel cell-based methods, and on the detection of PSA via its glycan part. The next main section covers optical biosensors, with subsections on methods making use of surface plasmon resonance (SPR), localized SPR and plasmonic ELISA-like schemes. This is followed by subsections on methods based on the use of fiber optics, fluorescence, chemiluminescence, Raman scattering and SERS, electrochemiluminescence and cantilever-based methods. The most sensitive biosensors are the electrochemical ones, with lowest limits of detection (down to attomolar concentrations), followed by mass cantilever sensing and electrochemilumenescent strategies. Optical biosensors show lower performance, but are still more sensitive compared to standard ELISA. The most commonly applied nanomaterials are metal and carbon-based ones and their hybrid composites used for different amplification strategies. The most attractive sensing schemes are summarized in a Table. The review ends with a section on conclusions and perspectives. [Figure not available: see fulltext.]. 1 2017, Springer-Verlag GmbH Austria.
SponsorThe financial support received from the Slovak Scientific Grant Agency VEGA 2/0162/14 and the Slovak Research and Development Agency APVV-14-0753 is acknowledged. The research leading to these results received funding from the European Research Council under the European Union?s Seventh Framework Program (FP/2007-2013)/ERC grant agreement number 311532. This publication was made possible by NPRP grant number 6-381-1-078 from the Qatar National Research Fund (a member of the Qatar Foundation). The statements made herein are solely the responsibility of the authors. This publication is the result of the project implementation: Centre for materials, layers and systems for applications and chemical processes under extreme conditions ? Stage I, ITMS No.: 26240120007, supported by the Research & Development Operational Program funded by the ERDF. The author(s) declare that they have no competing interests.
Languageen
PublisherSpringer-Verlag Wien
SubjectBiochip
Biomarker
Cantilever
Electroanalysis
Electrochemiluminescence
Nanomaterial
Nanotechnology
Optical Assays
Prostate Cancer
PSA
TitleNanomaterial-based biosensors for detection of prostate specific antigen
TypeArticle Review
Pagination3049-3067
Issue Number9
Volume Number184


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