DNA Damage/Repair Management in Cancers
الملخص
DNA damage can alter nucleotide sequences and lead to expression of dysfunctional proteins that impact normal cellular physiology. Sources of DNA damage can be endogenous or exogenous and include reactive oxygen species (ROS) or ionizing radiation. DNA damaging agents can broadly be classified into two different categories: clastogens and aneugens. Clastogens cause chromosomal breaks and induce micronuclei (MN) due to generation of acentric chromosomal fragments. In contrast, aneugens lead to the incorporation of whole chromosomes in MN by generation of aneuploidy that affects cell proliferation and the mitotic spindle apparatus
معرّف المصادر الموحد
https://www.routledge.com/Advances-in-Medical-Biochemistry-Genomics-Physiology-and-Pathology/Bawa-Chang-Audette-Diwan-Faiz/p/book/9789814877442#DOI/handle
http://hdl.handle.net/10576/25103المجموعات
- أبحاث الطب [1340 items ]
وثائق ذات صلة
عرض الوثائق المتصلة بواسطة: العنوان، المؤلف، المنشئ والموضوع.
-
Optimal replacement last with continuous and discrete policies
Zhao, X.; Nakagawa, T.; Zuo, M.J. ( Institute of Electrical and Electronics Engineers Inc. , 2014 , Article)This paper proposes age and periodic replacement last models with continuous, and discrete policies. That is, an operating unit is replaced preventively at time T of operation as a strategic policy, or at a number N of ... -
Strengthening of RC beams using near surface embedded-FRCM
Ebead, Usama A; El-Sherif, Hossameldin ( ISEC Press , 2019 , Conference Paper)Fibre reinforced cementitious matrix (FRCM) systems are mostly externally bonded (EB) for the strengthening of reinforced concrete (RC) and masonry structures. In this paper, the relatively new concept of near-surface ... -
Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects
Alsaad A.M.; Al-Arifi M.N.; Maayah Z.H.; Attafi I.M.; Alanazi F.E.; Belali O.M.; Alhoshani A.; Asiri Y.A.; Korashy H.M.... more authors ... less authors ( Taylor and Francis Ltd , 2019 , Article)Although a plethora of studies have examined tobacco smoke-cancer disease association, the involvement of cellular genetic toxicity remains unclear. Therefore, the present study provides molecular evidence for a pathway ...