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AuthorZupin, L.
AuthorZupin, Luisa
AuthorGratton, Rossella
AuthorFontana, Francesco
AuthorClemente, Libera
AuthorPascolo, Lorella
AuthorRuscio, Maurizio
AuthorCrovella, Sergio
Available date2022-01-24T05:24:41Z
Publication Date2021-04-01
Publication NameJournal of Biophotonics
Identifierhttp://dx.doi.org/10.1002/jbio.202000496
CitationZupin, L, Gratton, R, Fontana, F, et al. Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells. J. Biophotonics. 2021; 14:e202000496. https://doi.org/10.1002/jbio.202000496
ISSN1864063X
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85101809002&origin=inward
URIhttp://hdl.handle.net/10576/25805
AbstractThe study of any intervention able to counteract SARS-CoV-2 pandemic is considerably envisaged. It was previously shown, in in vitro models of infections, that the LED blue light is able to decrease the viral load of HSV-1 and ZIKV. In our study, LED photobiomodulation therapy (PBMT) at blue wavelengths (450, 454 and 470 nm) was tested in an in vitro model of SARS-CoV-2 infection, employing three experimental settings: SARS-CoV-2 was irradiated and then transferred to cells; already infected cells were irradiated; cells were irradiated prior to infection. A decrement of the viral load was observed when previously infected cells were irradiated with all three tested wavelengths and relevant effects were registered especially at 48 hours post-infection, possibly suggesting that the blue light could interfere with the intracellular viral replication machinery. Our in vitro findings could represent the starting point for translational applications of PBMT as a supportive approach to fight SARS-CoV-2.
Languageen
PublisherWiley
Subjectblue LED
photobiomodulation therapy
SARS-CoV-2
Vero E6 cell line
TitleBlue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells
TypeOther
Issue Number4
Volume Number14
ESSN1864-0648
dc.accessType Full Text


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