A Nonovershooting Controller with Integral Action for Multi-input Multi-output Drug Dosing Control ?
المؤلف | Padmanabhan, R. |
المؤلف | Meskin, Nader |
المؤلف | Ionescu, C.M. |
المؤلف | Haddad, W.M. |
تاريخ الإتاحة | 2022-04-14T08:45:41Z |
تاريخ النشر | 2018 |
اسم المنشور | IFAC-PapersOnLine |
المصدر | Scopus |
المعرّف | http://dx.doi.org/10.1016/j.ifacol.2018.06.029 |
الملخص | In this paper, a nonovershooting tracking controller is proposed for the continuous infusion of multiple drugs that have interactive effects. The proposed controller design method exploits the freedom of eigenstructure assignment pertinent to the design of feedback controllers for multi-input, multi-output (MIMO) systems. For drug dosing, a nonovershooting tracking controller restricts the undesirable side effects of drug overdosing. The proposed tracking controller is based on an estimate of the full state using a hybrid extended Kalman filter (EKF) that is used to reconstruct the system states from the measurable system outputs. An integral control action is included in the controller design to achieve robust tracking in the presence of patient parameter uncertainty. Simulation results and performance analysis of the proposed control strategy are also presented using 20 simulated patients. 2018 |
راعي المشروع | Qatar National Research Fund |
اللغة | en |
الناشر | Elsevier B.V. |
الموضوع | Controlled drug delivery Drug interactions Extended Kalman filters MIMO systems Active drugs Biomedical control Controller design method Eigenstructure assignment Hybrid extended kalman filters Multi input multi output Multi-input , multi-output systems Nonovershooting tracking controllers Controllers |
النوع | Conference Paper |
الصفحات | 60-65 |
رقم العدد | 4 |
رقم المجلد | 51 |
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