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AuthorPadmanabhan, R.
AuthorMeskin, Nader
AuthorIonescu, C.M.
AuthorHaddad, W.M.
Available date2022-04-14T08:45:41Z
Publication Date2018
Publication NameIFAC-PapersOnLine
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.ifacol.2018.06.029
URIhttp://hdl.handle.net/10576/29789
AbstractIn this paper, a nonovershooting tracking controller is proposed for the continuous infusion of multiple drugs that have interactive effects. The proposed controller design method exploits the freedom of eigenstructure assignment pertinent to the design of feedback controllers for multi-input, multi-output (MIMO) systems. For drug dosing, a nonovershooting tracking controller restricts the undesirable side effects of drug overdosing. The proposed tracking controller is based on an estimate of the full state using a hybrid extended Kalman filter (EKF) that is used to reconstruct the system states from the measurable system outputs. An integral control action is included in the controller design to achieve robust tracking in the presence of patient parameter uncertainty. Simulation results and performance analysis of the proposed control strategy are also presented using 20 simulated patients. 2018
SponsorQatar National Research Fund
Languageen
PublisherElsevier B.V.
SubjectControlled drug delivery
Drug interactions
Extended Kalman filters
MIMO systems
Active drugs
Biomedical control
Controller design method
Eigenstructure assignment
Hybrid extended kalman filters
Multi input multi output
Multi-input , multi-output systems
Nonovershooting tracking controllers
Controllers
TitleA Nonovershooting Controller with Integral Action for Multi-input Multi-output Drug Dosing Control ?
TypeConference Paper
Pagination60-65
Issue Number4
Volume Number51
dc.accessType Abstract Only


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