Browsing Medicine Research by Title

Now showing items 179-198 of 1337

    • Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021 

      Stein Emil, Vollset; Ababneh, Hazim S; Abate, Yohannes Habtegiorgis; Abbafati, Cristiana; Abbasgholizadeh, Rouzbeh; ... more authors ( Elsevier , 2024 , Article)
      BackgroundFuture trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and ...

    • Burnout and job satisfaction among psychiatrists in the Mental Health Service, Hamad Medical Corporation, Qatar 

      Kader, Nisha; Elhusein, Bushra; Elhassan, Nahid M.; Alabdulla, Majid; Hammoudeh, Samer; ... more authors ( Elsevier , 2021 , Article)
      Background: Job satisfaction is a critical concern among medical staff and directly affects patient safety and quality of health care services. Burnout has been reported to be correlated with job satisfaction. Aims: This ...

    • Buspirone in the management of refractory irritable bowel syndrome A case report 

      Karim, Mustafa Abdul; Al-Baz, Nadeen; Haddad, Peter M.; Reagu, Shuja M.; Alabdulla, Majid ( Lippincott Williams and Wilkins , 2021 , Article)
      Rationale: Irritable bowel syndrome (IBS) is a chronic and debilitating functional disorder of the gastrointestinal tract manifested by abdominal pain and bowel habit dysregulation. The pathophysiology is complex and ...

    • C-peptide in diabetes: A player in a dual hormone disorder? 

      Dakroub, Ali; Dbouk, Ali; Asfour, Aref; Nasser, Suzanne A.; El-Yazbi, Ahmed F.; ... more authors ( Wiley-Blackwell , 2024 , Article)
      C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) ...

    • Calmodulin Interacts and Regulates Enzyme Activity of the Mammalian Sperm Phospholipase C 

      Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Theodoridou, Maria; Buntwal, Luke; ... more authors ( Elsevier , 2017 , Article)
      Sperm-specific Phospholipase C zeta (PLCζ) is widely considered to be the sole, physiological stimulus responsible for the generation of Ca2+ oscillations that induce egg activation and early embryo development during ...

    • Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics 

      Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Beck, Konrad; Vassilakopoulou, Vyronia; ... more authors ( Elsevier , 2018 , Article)
      Calmodulin (CaM) is a cytoplasmic multifunctional calcium (Ca2+)-binding messenger that interacts with the cardiac ryanodine receptor (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ...

    • Can atorvastatin with metformin change the natural history of prostate cancer as characterized by molecular, metabolomic, imaging and pathological variables? A randomized controlled trial protocol 

      Roberts, Matthew J.; Yaxley, John W.; Coughlin, Geoffrey D.; Gianduzzo, Troy R.J.; Esler, Rachel C.; ... more authors ( Elsevier , 2016 , Article)
      Background Atorvastatin and metformin are known energy restricting mimetic agents that act synergistically to produce molecular and metabolic changes in advanced prostate cancer (PCa). This trial seeks to determine whether ...

    • Cannabinoids and Myocardial Ischemia: Novel insights, Updated Mechanisms, and Implications for Myocardial Infarction 

      El Dahan, Karim Seif; Machtoub, Dima; Massoud, Gaelle; Nasser, Suzanne A.; Hamam, Bassam; ... more authors ( Bentham Science Publishers , 2022 , Article)
      Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects ...

    • Carbimazole-Induced Jaundice in Thyrotoxicosis: A Case Report. 

      Maliyakkal, Abdul Majeed; A Elhadd, Tarik A; Naushad, Vamanjore A; Shaath, Nabeel M; Farfar, Khalifa L; ... more authors ( Springer , 2021 , Article)
      Carbimazole is a commonly used antithyroid drug in thyrotoxicosis. It is generally well tolerated, and its side effects include allergic skin reactions, gastrointestinal upset, agranulocytosis, and hepatotoxicity. Hepatitis ...

    • Carcinoma with apocrine differentiation 

      Provenzano, E; Gatalica, Z; Vranic, S ( World Health Organization , 2019 , Book chapter)
      Carcinoma with apocrine differentiation is a rare subtype constituting ~1% of all invasive breast carcinomas. Patients tend to be older compared with patients with invasive breast carcinomas NST. Essential criteria: Invasive ...

    • Cardiac Arrest in an Adolescent Boy Due to the Anomalous Origin of the Left Main Coronary Artery: Emergency Department Perspective. 

      Malik, Waseem; Younis, Hasan; Ponappan, Benny; Bashir, Khalid; Elmoheen, Amr ( Cureus , 2022 , Article)
      Congenital anomalies of the origin of the coronary arteries are rare. Multiple anomalies have been reported where the common one is left circumflex arising from the right sinus of Valsalva (RSV). Other anomalies are a ...

    • Cardiac autonomic neuropathy: A progressive consequence of chronic low-grade inflammation in type 2 diabetes and related metabolic disorders 

      Bakkar, Nour-Mounira Z.; Dwaib, Haneen S.; Fares, Souha; Eid, Ali H.; Al-Dhaheri, Yusra; ... more authors ( MDPI , 2020 , Article Review)
      Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes (T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research relates the pathogenesis of cardiovascular ...

    • Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats 

      Hosseini, Azar; Safari, Mohammad Kazem; Rajabian, Arezoo; Boroumand-Noughabi, Samaneh; Eid, Ali H.; ... more authors ( Frontiers Media S.A. , 2022 , Article)
      Background: Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum ...

    • Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats 

      Hosseini, Azar; Ghorbani, Atieh; Alavi, Mohaddeseh Sadat; Forouhi, Nima; Rajabian, Arezoo; ... more authors ( Frontiers Media SA , 2023 , Article)
      Introduction: Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or ...

    • Cardiovascular risk assessment for patients with serious mental illnesses: An internal review 

      Alshawwaf, Mahmoud; Delson Molina, John; Eltotrki, Yassin; Adil Shah Khoodoruth, Mohamed; Alabdulla, Majid ( Hamad bin Khalifa University Press (HBKU Press) , 2021 , Article)
      Cardiovascular diseases (CVD) are the leading cause of excess premature mortality among patients with serious mental illness (SMI), mainly because of higher cardiovascular risk and metabolic syndrome compared to the general ...

    • Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells 

      Alsamri, Halima; Alneyadi, Aysha; Muhammad, Khalid; Ayoub, Mohammed Akli; Eid, Ali; ... more authors ( Frontiers , 2022 , Article)
      We recently reported that carnosol induces ROS-dependent autophagy and apoptosis in breast cancer cells. We also reported that carnosol inhibits breast cancer cell migration, invasion, and in ovo tumor growth, as well as ...

    • Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer 

      Alsamri, Halima; Hasasna, Hussain El; Baby, Bincy; Alneyadi, Aysha; Dhaheri, Yusra Al; ... more authors ( Frontiers Media S.A. , 2021 , Article)
      Carnosol, a natural polyphenol abundant in edible plants such as sage, rosemary, and oregano, has shown promising anticancer activity against various types of cancers. Nonetheless, very little is known about its molecular ...

    • CCN3, POSTN, and PTHLH as potential key regulators of genomic integrity and cellular survival in iPSCs 

      Swaidan, Nuha T.; Soliman, Nada H.; Aboughalia, Ahmed T.; Darwish, Toqa; Almeshal, Ruba O.; ... more authors ( Frontiers Media SA , 2024 , Article)
      Reprogramming human somatic cells into a pluripotent state, achieved through the activation of well-defined transcriptional factors known as OSKM factors, offers significant potential for regenerative medicine. While OSKM ...

    • Cell shortening and calcium dynamics in epicardial and endocardial myocytes from the left ventricle of Goto-Kakizaki type 2 diabetic rats 

      Smail M.; Al Kury L.; Qureshi M.A.; Shmygol A.; Oz M.; ... more authors ( Blackwell Publishing Ltd , 2018 , Article)
      New Findings: What is the central question of this study? To investigate haemodynamic dysfunction in the type 2 diabetic Goto-Kakizaki (GK) rat, we measured shortening and Ca2+ transport in ventricular myocytes from ...

    • Cell-based diagnostic of bronchial carcinoma: Case study of a diagnostic value of tests of circulating tumor cells and organoid culture 

      Souchelnytskyi, N.; Kost, A.; Souchelnytskyi, S. ( Danylo Halytskyi Lviv National Medical University , 2020 , Article)
      Diagnostic based on analysis of living tumor cells is frequently used in oncology. Circulating tumor cells in the blood and cells obtained from a tumor biopsy are used to access their carcinogenic properties and subsequently ...