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NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs
(
Walter de Gruyter
, 2022 , Article)
Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and ...
Epac as a tractable therapeutic target
(
Elsevier
, 2023 , Article)
In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ...
Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrations
(
Springer Nature
, 2023 , Article)
In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these effects have been reported in cancerous ...
Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
(
Elsevier
, 2021 , Article)
Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients’ quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines ...
Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
(
MDPI
, 2023 , Article)
Cancer is the second most life-threatening disease and has become a global health and economic problem worldwide. Due to the multifactorial nature of cancer, its pathophysiology is not completely understood so far, which ...
Effects of Trehalose Administration in Patients with Mucopolysaccharidosis Type III.
(
Europe PMC
, 2023 , Article)
Mucopolysaccharidosis type III (MPS III) is a rare autosomal recessive lysosomal storage disease (LSD) caused by a deficiency of lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs), mainly in the ...
MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications.
(
Europe PM
, 2023 , Article)
One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ...
Exploring serum glycome patterns after moderate to severe traumatic brain injury: A prospective pilot study
(
Elsevier
, 2022 , Article)
BackgroundGlycans play essential functional roles in the nervous system and their pathobiological relevance has become increasingly recognized in numerous brain disorders, but not fully explored in traumatic brain injury ...
Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease
(
Elsevier
, 2022 , Article)
Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by statins is affected by inhibiting the active site of the enzyme in a competitive manner. Statins reduce plasma cholesterol by inhibiting its de novo ...
Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain
(
Elsevier
, 2022 , Article)
Human exposure to bisphenol A (BPA) is mainly due to migration from plastic packaging into food and beverages. Studies reported BPA endocrine disruptions through interactions with different nuclear receptors, including the ...