Browsing Research Units by Author "Uddin, Shahab"
Now showing items 1-20 of 41
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Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells
Kuttikrishnan, Shilpa; Bhat, Ajaz A.; Mateo, Jericha M.; Ahmad, Fareed; Alali, Feras Q.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article)Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by ... -
Applications of polydopaminic nanomaterials in mucosal drug delivery
Takwa, Bedhiafi; Idoudi, Sourour; Alhams, Areej Ali; Fernandes, Queenie; Iqbal, Heba; Basineni, Renuka; Uddin, Shahab; Dermime, Said; Merhi, Maysaloun; Billa, Nashiru... more authors ... less authors ( Elsevier , 2023 , Article Review)Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic ... -
Association of genes with phenotype in autism spectrum disorder.
Nisar, Sabah; Hashem, Sheema; Bhat, Ajaz A; Syed, Najeeb; Yadav, Santosh; Azeem, Muhammad Waqar; Uddin, Shahab; Bagga, Puneet; Reddy, Ravinder; Haris, Mohammad... more authors ... less authors ( Impact Journals , 2019 , Article Review)Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder that is characterized by impairments in social interaction and speech development and is accompanied by stereotypical behaviors such as ... -
Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis
Kuttikrishnan, Shilpa; Masoodi, Tariq; Sher, Gulab; Bhat, Ajaz A.; Patil, Kalyani; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Haris, Mohmmad; Ahmad, Aamir; Alali, Feras Q.; Uddin, Shahab... more authors ... less authors ( Frontiers Media S.A. , 2022 , Article)Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic ... -
Claudin-1, A Double-Edged Sword in Cancer.
Bhat, Ajaz A; Syed, Najeeb; Therachiyil, Lubna; Nisar, Sabah; Hashem, Sheema; Macha, Muzafar A; Yadav, Santosh K; Krishnankutty, Roopesh; Muralitharan, Shanmugakonar; Al-Naemi, Hamda; Bagga, Puneet; Reddy, Ravinder; Dhawan, Punita; Akobeng, Anthony; Uddin, Shahab; Frenneaux, Michael P; El-Rifai, Wael; Haris, Mohammad... more authors ... less authors ( MDPI , 2020 , Article Review)Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated ... -
Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance (Molecular Cancer, (2020), 19, 1, (57), 10.1186/s12943-020-01175-9)
Bhat, Ajaz A.; Younes, Salma N.; Raza, Syed Shadab; Zarif, Lubna; Nisar, Sabah; Ahmed, Ikhlak; Mir, Rashid; Kumar, Sachin; Sharawat, Surender K.; Hashem, Sheema; Elfaki, Imadeldin; Kulinski, Michal; Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Khan, Abdul Q.; Yadav, Santosh K.; El-Rifai, Wael; Zargar, Mohammad A.; Zayed, Hatem; Haris, Mohammad; Uddin, Shahab... more authors ... less authors ( BMC , 2020 , Other)Following the publication of the original article [1], authors have noticed that one of the authors, Syed Shadab Raza, was missing in the Authors’ Contributions section. Please see below updated section. -
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
Sharma, Tarang; Gupta, Ashna; Chauhan, Ravi; Bhat, Ajaz A.; Nisar, Sabah; Hashem, Sheema; Akhtar, Sabah; Ahmad, Aamir; Haris, Mohammad; Singh, Mayank; Uddin, Shahab... more authors ... less authors ( Springer , 2022 , Article)Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like ... -
Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
Bhat, Ajaz A.; Nisar, Sabah; Singh, Mayank; Ashraf, Bazella; Masoodi, Tariq; Prasad, Chandra P.; Sharma, Atul; Maacha, Selma; Karedath, Thasni; Hashem, Sheema; Yasin, Syed Besina; Bagga, Puneet; Reddy, Ravinder; Frennaux, Michael P.; Uddin, Shahab; Dhawan, Punita; Haris, Mohammad; Macha, Muzafar A.... more authors ... less authors ( Wiley , 2022 , Article Review)Colorectal cancer (CRC) is a predominant life-threatening cancer, with liver and peritoneal metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor, nurtures a local inflammatory environment ... -
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
Bhat, A.A.; Bhat, Ajaz A.; Nisar, Sabah; Maacha, Selma; Carneiro-Lobo, Tatiana Correa; Akhtar, Sabah; Siveen, Kodappully Sivaraman; Wani, Nissar A.; Rizwan, Arshi; Bagga, Puneet; Singh, Mayank; Reddy, Ravinder; Uddin, Shahab; Grivel, Jean Charles; Chand, Gyan; Frenneaux, Michael P.; Siddiqi, Mushtaq A.; Bedognetti, Davide; El-Rifai, Wael; Macha, Muzafar A.; Haris, Mohammad... more authors ... less authors ( BMC , 2021 , Article Review)Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account ... -
Decoding the functional role of extracellular vesicles in hepatocellular carcinoma: implications in clinical theranostics
Kalyani, Patil; Dermime, Said; Uddin, Shahab ( Elsevier , 2022 , Book chapter)Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer in adults, the sixth most commonly diagnosed neoplasia, and the third leading cause of cancer-related deaths worldwide. Despite tangible ... -
Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
Fernandes, Queenie; Inchakalody, Varghese Philipose; Merhi, Maysaloun; Mestiri, Sarra; Taib, Nassiba; Moustafa Abo El-Ella, Dina; Bedhiafi, Takwa; Raza, Afsheen; Al-Zaidan, Lobna; Mohsen, Mona O.; Yousuf Al-Nesf, Mariam Ali; Hssain, Ali Ait; Yassine, Hadi Mohamad; Bachmann, Martin F.; Uddin, Shahab; Dermime, Said... more authors ... less authors ( Taylor and Francis , 2022 , Article)The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for change in the form of newer and more adaptive diagnostic methods for the detection of SARS-CoV-2 infections. On the other hand, developing ... -
Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications.
Sher, Gulab; Salman, Nadia Aziz; Khan, Abdul Q; Prabhu, Kirti S; Raza, Afsheen; Kulinski, Michal; Dermime, Said; Haris, Mohammad; Junejo, Kulsoom; Uddin, Shahab... more authors ... less authors ( Elsevier , 2020 , Article Review)The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor ... -
Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions
Alsayed, Reem Khaled M.E.; Sheikhan, Khalid Sultan A.M.; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier , 2023 , Article Review)Cancer ‘stemness’ is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the ... -
Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression
Reem Khaled M.E., Alsayed; Khan, Abdul Q.; Ahmad, Fareed; Ansari, Abdul Wahid; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier , 2022 , Article)Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent ... -
Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance.
Maacha, Selma; Bhat, Ajaz A; Jimenez, Lizandra; Raza, Afsheen; Haris, Mohammad; Uddin, Shahab; Grivel, Jean-Charles... more authors ... less authors ( Springer Verlag , 2019 , Article)The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of the tumor ... -
F-box proteins in cancer stemness: An emerging prognostic and therapeutic target
Abdul Q., Khan; Al-Tamimi, Maha; Uddin, Shahab; Steinhoff, Martin ( Elsevier , 2021 , Article)Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, ... -
Functional In Vivo Imaging of Tumors.
Haris, Mohammad; Nisar, Sabah; Hashem, Sheema; Bhat, Ajaz A; Yadav, Santosh; Shanmugakonar, Muralitharan; Al-Naemi, Hamda; Bagga, Puneet; Uddin, Shahab; Reddy, Ravinder... more authors ... less authors ( Springer , 2020 , Book chapter)Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the ... -
Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder.
Nisar, Sabah; Bhat, Ajaz A; Hashem, Sheema; Syed, Najeeb; Yadav, Santosh K; Uddin, Shahab; Fakhro, Khalid; Bagga, Puneet; Thompson, Paul; Reddy, Ravinder; Frenneaux, Michael P; Haris, Mohammad... more authors ... less authors ( MDPI , 2020 , Article Review)Post-traumatic stress disorder (PTSD) is a highly disabling condition, increasingly recognized as both a disorder of mental health and social burden, but also as an anxiety disorder characterized by fear, stress, and ... -
Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells
Abdulrahman, Nabeel; Siveen, Kodappully Sivaraman; Joseph, Jensa Mariam; Osman, Aisha; Yalcin, Huseyin C.; Hasan, Anwarul; Uddin, Shahab; Mraiche, Fatima... more authors ... less authors ( Wiley , 2020 , Article)© 2020 Royal Pharmaceutical Society Aim: Cisplatin is a standard treatment approach against lung adenocarcinoma. Resistance to cisplatin and the toxic side effects of cisplatin continue to remain a challenge. Combining ... -
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies
Nisar, Sabah; Bhat, Ajaz A.; Singh, Mayank; Karedath, Thasni; Rizwan, Arshi; Hashem, Sheema; Bagga, Puneet; Reddy, Ravinder; Jamal, Farrukh; Uddin, Shahab; Chand, Gyan; Bedognetti, Davide; El-Rifai, Wael; Frenneaux, Michael P.; Macha, Muzafar A.; Ahmed, Ikhlak; Haris, Mohammad... more authors ... less authors ( Frontiers Media , 2021 , Article Review)Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with decreased ...