Show simple item record

AuthorAbdul Q., Khan
AuthorRashid, Khalid
AuthorAlAmodi, Abdulhadi A.
AuthorAgha, Maha Victor
AuthorAkhtar, Sabah
AuthorHakeem, Ishrat
AuthorRaza, Syed Shadab
AuthorUddin, Shahab
Available date2022-12-29T05:25:07Z
Publication Date2021-11-30
Publication NameBiomedicine & Pharmacotherapy
Identifierhttp://dx.doi.org/10.1016/j.biopha.2021.112142
CitationKhan, A. Q., Rashid, K., AlAmodi, A. A., Agha, M. V., Akhtar, S., Hakeem, I., ... & Uddin, S. (2021). Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids. Biomedicine & Pharmacotherapy, 143, 112142.
ISSN07533322
URIhttps://www.sciencedirect.com/science/article/pii/S0753332221009264
URIhttp://hdl.handle.net/10576/37764
AbstractReactive oxygen species play crucial role in biological homeostasis and pathogenesis of human diseases including cancer. In this line, now it has become evident that ROS level/concentration is a major factor in the growth, progression and stemness of cancer cells. Moreover, cancer cells maintain a delicate balance between ROS and antioxidants to promote pathogenesis and clinical challenges via targeting a battery of signaling pathways converging to cancer hallmarks. Recent findings also entail the therapeutic importance of ROS for the better clinical outcomes in cancer patients as they induce apoptosis and autophagy. Moreover, poor clinical outcomes associated with cancer therapies are the major challenge and use of natural products have been vital in attenuation of these challenges due to their multitargeting potential with less adverse effects. In fact, most available drugs are derived from natural resources, either directly or indirectly and available evidence show the clinical importance of natural products in the management of various diseases, including cancer. ROS play a critical role in the anticancer actions of natural products, particularly phytochemicals. Benzophenanthridine alkaloids of the benzyl isoquinoline family of alkaloids, such as sanguinarine, possess several pharmacological properties and are thus being studied for the treatment of different human diseases, including cancer. In this article, we review recent findings, on how benzophenanthridine alkaloid-induced ROS play a critical role in the attenuation of pathological changes and stemness features associated with human cancers. In addition, we highlight the role of ROS in benzophenanthridine alkaloid-mediated activation of the signaling pathway associated with cancer cell apoptosis and autophagy.
Languageen
PublisherElsevier
SubjectROS
Cancer
Oxidative stress
Natural products
Benzophenanthridine alkaloids
Cancer stemness
TitleReactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids
TypeArticle
Volume Number143
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Full Text


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record