Show simple item record

AuthorRinchai, Darawan
AuthorDeola, Sara
AuthorZoppoli, Gabriele
AuthorKabeer, Basirudeen Syed Ahamed
AuthorTaleb, Sara
AuthorPavlovski, Igor
AuthorMaacha, Selma
AuthorGentilcore, Giusy
AuthorToufiq, Mohammed
AuthorMathew, Lisa
AuthorLiu, Li
AuthorVempalli, Fazulur Rehaman
AuthorMubarak, Ghada
AuthorLorenz, Stephan
AuthorSivieri, Irene
AuthorCirmena, Gabriella
AuthorDentone, Chiara
AuthorCuccarolo, Paola
AuthorGiacobbe, Daniele Roberto
AuthorBaldi, Federico
AuthorGarbarino, Alberto
AuthorCigolini, Benedetta
AuthorCremonesi, Paolo
AuthorBedognetti, Michele
AuthorBallestrero, Alberto
AuthorBassetti, Matteo
AuthorHejblum, Boris P.
AuthorAugustine, Tracy
AuthorVan Panhuys, Nicholas
AuthorThiebaut, Rodolphe
AuthorBranco, Ricardo
AuthorChew, Tracey
AuthorShojaei, Maryam
AuthorShort, Kirsty
AuthorFeng, Carl G.
AuthorZughaier, Susu M.
AuthorDe Maria, Andrea
AuthorTang, Benjamin
AuthorHssain, Ali Ait
AuthorBedognetti, Davide
AuthorGrivel, Jean Charles
AuthorChaussabel, Damien
Available date2023-01-11T08:36:24Z
Publication Date2022-11-11
Publication NameScience Advances
Identifierhttp://dx.doi.org/10.1126/sciadv.abp9961
CitationRinchai D, Deola S, Zoppoli G, Kabeer BSA, Taleb S, Pavlovski I, Maacha S, Gentilcore G, Toufiq M, Mathew L, Liu L, Vempalli FR, Mubarak G, Lorenz S, Sivieri I, Cirmena G, Dentone C, Cuccarolo P, Giacobbe DR, Baldi F, Garbarino A, Cigolini B, Cremonesi P, Bedognetti M, Ballestrero A, Bassetti M, Hejblum BP, Augustine T, Van Panhuys N, Thiebaut R, Branco R, Chew T, Shojaei M, Short K, Feng CG; PREDICT-19 Consortium; Zughaier SM, De Maria A, Tang B, Ait Hssain A, Bedognetti D, Grivel JC, Chaussabel D. High-temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines. Sci Adv. 2022 Nov 11;8(45):eabp9961. doi: 10.1126/sciadv.abp9961.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85141670852&origin=inward
URIhttp://hdl.handle.net/10576/38314
AbstractKnowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via high–temporal resolution blood transcriptome profiling. The first vaccine dose elicited modest interferon and adaptive immune responses, which peaked on days 2 and 5, respectively. The second vaccine dose, in contrast, elicited sharp day 1 interferon, inflammation, and erythroid cell responses, followed by a day 5 plasmablast response. Both post-first and post-second dose interferon signatures were associated with the subsequent development of antibody responses. Yet, we observed distinct interferon response patterns after each of the doses that may reflect quantitative or qualitative differences in interferon induction. Distinct interferon response phenotypes were also observed in patients with COVID-19 and were associated with severity and differences in duration of intensive care. Together, this study also highlights the benefits of adopting high-frequency sampling protocols in profiling vaccine-elicited immune responses.
Languageen
PublisherAmerican Association for the Advancement of Science
SubjectmRNA vaccine
SARS-CoV2
COVID19
Transcriptomics
Immune responses
TitleHigh–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
TypeArticle
Issue Number45
Volume Number8
ESSN2375-2548
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record