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AuthorOftadeh, R.
AuthorKarimi, Z.
AuthorVilla-Camacho, J.
AuthorTanck, E.
AuthorVerdonschot, N.
AuthorGoebel, R.
AuthorSnyder, B.D.
AuthorHashemi, H.N.
AuthorVaziri A.
AuthorNazarian, A.
Available date2016-10-16T11:39:19Z
Publication Date2016-09-02
Publication NameScientific Reports
Identifierhttp://dx.doi.org/10.1038/srep32397
CitationOftadeh, R. et al. Curved Beam Computed Tomography based Structural Rigidity Analysis of Bones with Simulated Lytic Defect: A Comparative Study with Finite Element Analysis. Sci. Rep. 6, 32397; (2016).
URIhttp://hdl.handle.net/10576/4892
AbstractIn this paper, a CT based structural rigidity analysis (CTRA) method that incorporates bone intrinsic local curvature is introduced to assess the compressive failure load of human femur with simulated lytic defects. The proposed CTRA is based on a three dimensional curved beam theory to obtain critical stresses within the human femur model. To test the proposed method, ten human cadaveric femurs with and without simulated defects were mechanically tested under axial compression to failure. Quantitative computed tomography images were acquired from the samples, and CTRA and finite element analysis were performed to obtain the failure load as well as rigidities in both straight and curved cross sections. Experimental results were compared to the results obtained from FEA and CTRA. The failure loads predicated by curved beam CTRA and FEA are in agreement with experimental results. The results also show that the proposed method is an efficient and reliable method to find both the location and magnitude of failure load. Moreover, the results show that the proposed curved CTRA outperforms the regular straight beam CTRA, which ignores the bone intrinsic curvature and can be used as a useful tool in clinical practices.
SponsorBeth Israel Deaconess Medical Center Department of Orthopaedic Surgery, the NIH LRP (L30 AR056606) (A.N.), and in part by a NPRP award (NPRP 5-086-2- 031) from the Qatar National Research Fund (a member of the Qatar Foundation)
Languageen
PublisherNature Publishing Group
SubjectBone cancer
Computational biophysics
TitleCurved Beam Computed Tomography based Structural Rigidity Analysis of Bones with Simulated Lytic Defect: A Comparative Study with Finite Element Analysis
TypeArticle
Volume Number6
ESSN2045-2322
dc.accessType Open Access


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