Determination of glafenine in dosage forms and serum by thin layer densitometry and high performance liquid chromatography
| Author | Hassan ,Saad S. M. |
| Author | Elnemma ,Eman M. |
| Author | Abbas, Alaa B |
| Available date | 2024-03-04T08:58:29Z |
| Publication Date | 1997 |
| Publication Name | Journal of Pharmaceutical and Biomedical Analysis |
| Resource | Scopus |
| ISSN | 0731-7085 |
| Abstract | New thin layer densitometry and high performance liquid chromatography (HPLC) methods are described for quantitative determination of glafenine in dosage forms in the presence of its photo-degradation products and in serum in the presence of its metabolites. Mobile phases consisting of toluene- isopropyl alcohol- dimethylformamide water (18:3:1:0.5) and methanol-water-phosphoric acid (80:120:0.5) are found to be efficient for reasonable separation and adequate resolution of glafenine from associated substances by thin layer chromatography (TLC) and HPLC techniques, respectively. The methods are used for the study of glafenine purity, stability, bioavailability, bioequivaIence and tablet dissolution rate. The results obtained by TLC and HPLC techniques are in good agreement and offer the advantages of reproducibility and accuracy. |
| Language | en |
| Publisher | Elsevier |
| Subject | Bioavailability Bioequivalence Glafenine assay Glafenine metabolites Glafenine photodegradation products High performance liquid chromatography Tablet dissolution rate Thin layer densitometry |
| Type | Article |
| Pagination | 215-221 |
| Issue Number | 2 |
| Volume Number | 16 |
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Chemistry & Earth Sciences [542 items ]