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المؤلفDoi, Suhail A R
المؤلفFuruya-Kanamori, Luis
المؤلفThalib, Lukman
المؤلفBarendregt, Jan J
تاريخ الإتاحة2017-12-31T05:22:24Z
تاريخ النشر2017-12-01
اسم المنشورInternational Journal of Evidence-Based Healthcare
المعرّفhttp://dx.doi.org/10.1097/XEB.0000000000000125
الاقتباسDoi, S. A., Furuya-Kanamori, L., Thalib, L., & Barendregt, J. J. (2017). Meta-analysis in evidence-based healthcare: a paradigm shift away from random effects is overdue. International journal of evidence-based healthcare, 15(4), 152-160.
الرقم المعياري الدولي للكتاب1744-1595
معرّف المصادر الموحدhttp://hdl.handle.net/10576/6044
الملخصEach year up to 20 000 systematic reviews and meta-analyses are published whose results influence healthcare decisions, thus making the robustness and reliability of meta-analytic methods one of the world's top clinical and public health priorities. The evidence synthesis makes use of either fixed-effect or random-effects statistical methods. The fixed-effect method has largely been replaced by the random-effects method as heterogeneity of study effects led to poor error estimation. However, despite the widespread use and acceptance of the random-effects method to correct this, it too remains unsatisfactory and continues to suffer from defective error estimation, posing a serious threat to decision-making in evidence-based clinical and public health practice. We discuss here the problem with the random-effects approach and demonstrate that there exist better estimators under the fixed-effect model framework that can achieve optimal error estimation. We argue for an urgent return to the earlier framework with updates that address these problems and conclude that doing so can markedly improve the reliability of meta-analytical findings and thus decision-making in healthcare.
اللغةen
الناشرUniversity of Adelaide, Joanna Briggs Institute
الموضوعcoverage
heterogeneity
inverse variance
meta-analysis
random effects
simulation
العنوانMeta-analysis in evidence-based healthcare: a paradigm shift away from random effects is overdue.
النوعArticle
الصفحات152-160
رقم العدد4
رقم المجلد15
ESSN1744-1609
dc.accessType Abstract Only


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