Browsing Biomedical Research Center by Title

Now showing items 275-294 of 666

    • From Acellular Matrices to Smart Polymers: Degradable Scaffolds that are Transforming the Shape of Urethral Tissue Engineering. 

      Abbas, Tariq O; Yalcin, Huseyin C; Pennisi, Cristian P ( MDPI , 2019 , Article)
      Several congenital and acquired conditions may result in severe narrowing of the urethra in men, which represent an ongoing surgical challenge and a significant burden on both health and quality of life. In the field of ...

    • From an Apple to a Pear: Moving Fat around for Reversing Insulin Resistance. 

      Alser, Maha; Elrayess, Mohamed A ( MDPI , 2022 , Article Review)
      Type 2 diabetes (T2D) is a chronic condition where the body is resistant to insulin, leading to an elevated blood glucose state. Obesity is a main factor leading to T2D. Many clinical studies, however, have described a ...

    • Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model 

      Da'as, Sahar I.; Yalcin, Huseyin C.; Nasrallah, Gheyath K.; Mohamed, Iman A.; Nomikos, Michail; ... more authors ( Wiley , 2020 , Article)
      © 2020 Wiley Periodicals, Inc. Myosin-binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical ...

    • Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar 

      Mohammed, Idris; Selvaraj, Senthil; Ahmed, Wesam S.; Al-Barazenji, Tara; Hammad, Ayat S.; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)
      The leptin–melanocortin pathway is pivotal in appetite and energy homeostasis. Pathogenic variants in genes involved in this pathway lead to severe early-onset monogenic obesity (MO). The MC4R gene plays a central role in ...

    • GATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus. 

      Al-Jaber, Hend; Al-Mansoori, Layla; Elrayess, Mohamed A ( PubMed Central , 2020 , Article Review)
      Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. The anti-adipogenic transcription factor GATA-3 was ...

    • Gene expression and miRNAs profiling: Function and regulation in human epidermal growth factor receptor 2 (HER2) - positive breast cancer 

      Sareyeldin, Rasha M.; Gupta, Ishita; Al-Hashimi, Israa; Al-Thawadi, Hamda A.; Al Farsi, Halema F.; ... more authors ( MDPI AG , 2019 , Article)
      Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 ...

    • Generating an imagingbased approach for enhanced structural and functional analysis of zebrafish cardiovascular systems 

      yalcin, huseyin c; Abuhabib, UmmaySalma; Kitaz, Naila; Mohamed, Ala; Zakaria, Zain ( HBKU Press , 2018 , Conference Proceedings)
      Cardiovascular diseases (CVDs) have latterly become one of the leading cause of death and impairment worldwide. According to the World Health Organization (WHO), data estimation in 2008 were about 17.3, 7.3 and 6.2 million ...

    • Genetic Diversity and Prevalence of in Qatar. 

      Chourabi, Marwa; Boughattas, Sonia; Abdallah, Atiyeh M; Ismail, Ahmed; Behnke, Jerzy M; ... more authors ( Frontiers Media , 2021 , Article)
      is a common human intestinal parasite worldwide, and the causative agent of diarrhea, with the severity of disease ranging from asymptomatic to intense and debilitating infection. is known to consist of eight genetically ...

    • Genetic relatedness and host specificity of Pseudomonas aeruginosa isolates from cystic fibrosis and non-cystic fibrosis patients 

      Abdulwahab, Atqah; Taj-Aldeen, Saad J.; Doiphode, S; Abdulla, Shaikha H.; Muhammed, Ramees; ... more authors ( Dove Medical Press Limited , 2014 , Article)
      Background: Pseudomonas aeruginosa is one of the primary pathogens isolated more frequently in cystic fibrosis (CF) and it exhibits innate resistance to a wide range of antibiotics. Purpose: We sought to determine whether ...

    • Genetic Susceptibility to Infectious Diseases in the Qatari Population 

      Smatti, Maria Khalid; Al-Sarraj, Yasser; Albagha, Omar Yassine, Hadi ( Qatar University Press , 2021 , Poster)
      Background: Infectious diseases (IDs) account for 8% of deaths annually in Qatar, and therefore, represent a significant challenge for public health. Interestingly, the spread and severity of viral infections vary considerably ...

    • Genetically unmatched human iPSC and ESC exhibit equivalent gene expression and neuronal differentiation potential. 

      Marei, Hany E; Althani, A; Lashen, S; Cenciarelli, C; Hasan, Anwarul ( Nature Publishing Group , 2017 , Article)
      The potential uniformity between differentiation and therapeutic potential of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) remains debatable. We studied the gene expression profiles, ...

    • Genome-wide association study identifies several loci for HEV seropositivity 

      Maria K., Smatti; Al-Sarraj, Yasser A.; Albagha, Omar; Yassine, Hadi M. ( Elsevier , 2023 , Article)
      Hepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we ...

    • Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism. 

      Al-Khelaifi, Fatima; Yousri, Noha A; Diboun, Ilhame; Semenova, Ekaterina A; Kostryukova, Elena S; ... more authors ( Frontiers Media , 2020 , Article)
      The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate ...

    • Geographical distribution of air pollution in Doha Qatar 

      Safi, Mariem; Ali Elobaid, Elnaiem ( Hamad bin Khalifa University Press (HBKU Press) , 2018 , Conference Paper)
      Urban air pollution is an inevitable consequence of the urbanization representing a growing concern to scientists, policymakers and an increasing fraction of the population. Air pollution is an acute problem especially in ...

    • Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application 

      Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Hasan, Anwarul; Caceci, Thomas; ... more authors ( Springer , 2022 , Article Review)
      EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to ...

    • A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway 

      Sartelli, Massimo; Kluger, Yoram; Ansaloni, Luca; Carlet, Jean; Brink, Adrian; ... more authors ( Mary Ann Liebert , 2017 , Article)
      This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use ...

    • Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses. 

      Boyoglu-Barnum, Seyhan; Hutchinson, Geoffrey B; Boyington, Jeffrey C; Moin, Syed M; Gillespie, Rebecca A; ... more authors ( Nature Research , 2020 , Article)
      The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the ...

    • Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia 

      Fernández-Murray1, J. Pedro; Prykhozhij, Sergey; Dufay, J. Noelia; Steele, Shelby; Gaston, Daniel; ... more authors ( Public Library of Science (USA) , 2016 , Article)
      Sideroblastic anemias are acquired or inherited anemias that result in a decreased ability to synthesize hemoglobin in red blood cells and result in the presence of iron deposits in the mitochondria of red blood cell ...

    • Glycine improves peritoneal vasoreactivity to dialysis solutions in the elderly 

      Zakaria, El Rasheid; Joseph, Bellal; Hamidi, Mohammad; Zeeshan, Muhammad; Algamal, Abdelrahman; ... more authors ( Hamad Medical Corporation , 2019 , Article)
      Background: Peritoneal dialysis solution (PDS) dilates peritoneal microvessels predominantly by the activation of the endothelial nitric oxide (NO) pathway. We made an incidental observation of decreased PDS-induced, ...

    • GOLD NANOPARTICLES-BASED ASSAYS FOR DIRECT AND COST EFFECTIVE DETECTION OF CLOSTRIDIUM DIFFICILE IN QATAR 

      Al-Saadi, Tahani Masoud Saleh (2015 , Master Thesis)
      Background Clostridium difficile Infection (CDI) is one of the common health problems worldwide. Prevention techniques require fast and precise detection with high sensitivity. Conventional diagnostic methods are ...