Browsing Laboratory Animal Research Center by Author "Varadharajan, Kavitha"
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Cadmium: An Emerging Role in Adipose Tissue Dysfunction
Attia, Sarra Mohammed; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Springer , 2021 , Article Review)Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and ... -
Cardiac Myosin Binding Protein-C in Sprague Dawley (SD) Rats exposed to Sub-Chronic oral dose of Cadmium Chloride
Al-Borshaid, Enjoud Khalifa; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda ( Qatar University Press , 2021 , Poster)Cadmium is one of the major environmental pollutants associated with an increment in industrial and urbanization activities. It has health consequences when it reaches the human diet through the soil, water, and plant. ... -
Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat
Das, Sandra Concepcion; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( Frontiers Media , 2021 , Article)The aim of this study was to evaluate the role of chronic cadmium exposure in modulating cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats were exposed to 15 ppm CdCl2 in drinking ... -
Early-Life Sugar Consumption Affects the Microbiome in Juvenile Mice
Alasmar, Reem Moath; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( John Wiley and Sons Inc , 2022 , Article)Scope: The composition of the gut microbiota is influenced by the dietary nutrient. Sugar has been linked with many metabolic health disorders such as heart disease, metabolic syndrome, and immune disorders. Long-term ... -
Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells
Shanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale (2017 , Poster)CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. ... -
Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK)
Shanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale (2016 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ... -
Gut Microbiota and Health: Understanding the Role of Diet
Alasmar, Reem Moath; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2019 , Article Review)Microbiome now is considered as an organ within our system to regulate metabolism, cellular immune response and eventually maintain the health. Gut microbiota has been studied extensively in the recent past due to the ... -
Gut Microbiota Dysbiosis and Their Impact on Biochemical and Inflammatory Profiles in Cafeteria Diet Fed Sprague Dawley Rats
Alasmar, Reem Moath; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2019 , Article)Gut microbiota plays a major role in regulating the host metabolism and immune system. However, the structure of microbiome population is altered constantly by diverse factors including diet and environment. In particular, ... -
Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats
Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2018 , Article)Diet plays a major role in the body physiology and metabolism. The quantity, nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a ... -
In Vitro Analysis of Psoriasis Linked CARMA2sh Gene in Keratinocytes and Mouse Embryonic Stem Cells towards Developing a Murine Transgenic Model
Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Vito, Pasquale ( American Association For Laboratory Animal Science , 2017 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. Genome-wide association studies have identified more than 40 susceptibility loci for psoriasis. CARMA2 proteins play a major role ...