Browsing Laboratory Animal Research Center by Author "Steinhoff, Martin"
Now showing items 1-6 of 6
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Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions
Alsayed, Reem Khaled M.E.; Sheikhan, Khalid Sultan A.M.; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier , 2023 , Article Review)Cancer ‘stemness’ is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the ... -
Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression
Reem Khaled M.E., Alsayed; Khan, Abdul Q.; Ahmad, Fareed; Ansari, Abdul Wahid; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier , 2022 , Article)Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent ... -
F-box proteins in cancer stemness: An emerging prognostic and therapeutic target
Abdul Q., Khan; Al-Tamimi, Maha; Uddin, Shahab; Steinhoff, Martin ( Elsevier , 2021 , Article)Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, ... -
Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients
Isaifan, Dina; Crovella, Sergio; Soubra, Lama; Al-Nesf, Maryam; Steinhoff, Martin ( MDPI , 2023 , Article Review)Atopic dermatitis (AD) is the most common chronic relapsing neuroinflammatory skin disease that is characterized by a complex and multifactorial pathophysiology. It reflects a profound interplay between genetic and ... -
Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways
Kalyani, Patil; Kuttikrishnan, Shilpa; Khan, Abdul Q.; Ahmad, Fareed; Alam, Majid; Buddenkotte, Joerg; Ahmad, Aamir; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article Review)Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex ... -
Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
Kirti.S., Prabhu; Bhat, Ajaz A.; Siveen, Kodappully S.; Kuttikrishnan, Shilpa; Raza, Syed Shadab; Raheed, Thesni; Jochebeth, Anh; Khan, Abdul Q.; Chawdhery, M.Zafar; Haris, Mohammad; Kulinski, Michal; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Elsevier , 2021 , Article)Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. The high mortality associated with this malignancy indicates ...