Browsing by Author "Althani, Asmaa"

Now showing items 1-18 of 18

    • A population study of clinically actionable genetic variation affecting drug response from the Middle East 

      Jithesh, Puthen Veettil; Abuhaliqa, Mohammed; Syed, Najeeb; Ahmed, Ikhlak; El Anbari, Mohammed; ... more authors ( Nature Research , 2022 , Article)
      Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is ...

    • Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) 

      Sartelli, Massimo; Weber, Dieter; Ruppé, Etienne; Bassetti, Matteo; Wright, Brian; ... more authors ( BioMed Central , 2016 , Article)
      Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely ...

    • Common and Rare Genetic Variants Associated With Alzheimer's Disease 

      Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; ... more authors ( WILEY PERIODICALS, INC. , 2016 , Article)
      Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis ...

    • Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application 

      Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Hasan, Anwarul; Caceci, Thomas; ... more authors ( Springer , 2022 , Article Review)
      EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to ...

    • Human Olfactory Bulb Neural Stem Cell Based Therapy for CNS Traumatic and Neurodegenerative Diseases 

      Marei, Hany; Althani, Asmaa ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)
      Neural stem cells (NSC) have self-renewal and multipotent properties and may serve as an ideal cell source for transplantation to treat neurodegenerative insults such as Parkinson's, Alzheimer's, and spinal cord injury ...

    • Human olfactory bulb neural stem cells (Hu-OBNSCs) can be loaded with paclitaxel and used to inhibit glioblastoma cell growth 

      Marei, Hany E.; Casalbore, Patrizia; Althani, Asmaa; Coccè, Valentina; Cenciarelli, Carlo; ... more authors ( MDPI , 2019 , Article)
      Exploitation of the potential ability of human olfactory bulb (hOB) cells to carry, release, and deliver an effective, targeted anticancer therapy within the central nervous system (CNS) milieu remains elusive. Previous ...

    • Human olfactory bulb neural stem cells mitigate movement disorders in a rat model of Parkinson's disease. 

      Marei, Hany E S; Lashen, Samah; Farag, Amany; Althani, Asmaa; Afifi, Nahla; ... more authors ( Wiley , 2015 , Article)
      Parkinson's disease (PD) is a neurological disorder characterized by the loss of midbrain dopaminergic (DA) neurons. Neural stem cells (NSCs) are multipotent stem cells that are capable of differentiating into different ...

    • Microfluidics integrated biosensors: A leading technology towards lab-on-a-chip and sensing applications 

      Luka, George; Ahmadi, Ali; Najjaran, Homayoun; Alocilja, Evangelyn; DeRosa, Maria; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2015 , Article)
      A biosensor can be defined as a compact analytical device or unit incorporating a biological or biologically derived sensitive recognition element immobilized on a physicochemical transducer to measure one or more analytes. ...

    • Over-Expression of hNGF in Adult Human Olfactory Bulb Neural Stem Cells Promotes Cell Growth and Oligodendrocytic Differentiation 

      Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Abd-Elmaksoud, Ahmed; Bernardini, Camilla; ... more authors ( Public Library of Science ONE Staff , 2013 , Article)
      The adult human olfactory bulb neural stem/progenitor cells (OBNC/PC) are promising candidate for cell-based therapy for traumatic and neurodegenerative insults. Exogenous application of NGF was suggested as a promising ...

    • Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches 

      Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Pozzoli, Giacomo; Caceci, Thomas; ... more authors ( Springer , 2021 , Article Review)
      We give a summary of SARS-genetic CoV-2’s structure and evolution, as well as current attempts to develop efficient vaccine and treatment methods for SARS-CoV-2 infection, in this article. Most therapeutic strategies are ...

    • Recent Perspective About the Amyloid Cascade Hypothesis and Stem Cell-Based Therapy in the Treatment of Alzheimer's Disease 

      Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; ... more authors ( Bentham Science , 2016 , Book chapter)
      Alzheimer's disease (AD) is a complex neurodegenerative condition that is clinically characterized by impaired cognitive functions. The major morphologically observed lesion of AD encompasses the accumulation of extracellular ...

    • Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus. 

      Sohail, Muhammad U; Althani, Asmaa; Anwar, Haseeb; Rizzi, Roberto; Marei, Hany E ( Hindawi Publishing Corporation , 2017 , Article)
      The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few ...

    • Seroprevalence of SARS-CoV2 in Qatar: a longitudinal epidemiological study 

      Shurrab, Farah; Al-Jighefee, Hadeel; Younes, Salma; Al-Sadeq, Duaa; Althani, Asmaa; ... more authors ( Qatar University Press , 2020 , Poster)
      In Qatar, the first COVID-19 cases were reported on the 29th of February 2020, and the numbers increased dramatically within few months. Primary Health Care Corporation in collaboration with Qatar University's Biomedical ...

    • The Effects of Class IV Hemorrhagic Hypotensive Shock and Its Resuscitation with Fluids and Adjuvant Vasopressors or Cellular Energy Replenishment on the Splanchnic Microcirculation 

      Zakaria, El Rasheid; Althani, Asmaa; El-Gamal, Abdul-Rahman; Sartaj, Faheem; Khan, Muhammad Jaffar; ... more authors ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)
      Traumatic exsanguination leading to class IV hemorrhagic shock as defined by the Committee on Trauma of the American College of Surgeons requires aggressive resuscitation with crystalloids and packed cells together with ...

    • The QChip1 knowledgebase and microarray for precision medicine in Qatar 

      Rodriguez-Flores, Juan L.; Messai-Badji, Radja; Robay, Amal; Temanni, Ramzi; Syed, Najeeb; ... more authors ( Nature Research , 2022 , Article)
      Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations, but pathogenic risk variants that cause SGDs are typically population-private. The goal was to develop "QChip1," an inexpensive ...

    • Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes 

      Razali, Rozaimi Mohamad; Rodriguez-Flores, Juan; Ghorbani, Mohammadmersad; Naeem, Haroon; Aamer, Waleed; ... more authors ( Nature Research , 2021 , Article)
      Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ...

    • Validation of Selected Commercial Serological Assays for Diagnosis of COVID-19 

      Younes, Salma; Al-Jighefee, Hadeel; Shurrab, Farah; Al-Sadeq, Duaa; Yassine, Hadi; ... more authors ( Qatar University Press , 2020 , Poster)
      As researchers around the globe rush to put the available antibody tests to use, concerns have been raised about their precision. This study aimed to evaluate and compare the performance of selected commercial & automated ...

    • Willingness to participate in genome testing: a survey of public attitudes from Qatar 

      Abdul-Rahim, Hanan; Ismail, Said; Hasan, Amel; Fadl, Tasnim; Khaled, Salma; ... more authors ( Springer , 2020 , Article)
      Genomics has the potential to revolutionize medical approaches to disease prevention, diagnosis, and treatment, but it does not come without challenges. The success of a national population-based genome program, like the ...