Browsing by Author "Zughaier, Susu M."
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An Adjuvanted Inactivated SARS-CoV-2 Microparticulate Vaccine Delivered Using Microneedles Induces a Robust Immune Response in Vaccinated Mice
Vijayanand, Sharon; Patil, Smital; Menon, Ipshita; Braz Gomes, Keegan; Kale, Akanksha; Bagwe, Priyal; Uddin, Mohammad N.; Zughaier, Susu M.; D’Souza, Martin J.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)SARS-CoV-2, the causal agent of COVID-19, is a contagious respiratory virus that frequently mutates, giving rise to variant strains and leading to reduced vaccine efficacy against the variants. Frequent vaccination against ... -
Anticorrosion Properties of Robust and UV-Durable Poly(vinylidene fluoride-co-hexafluoropropylene)/Carbon Nanotubes Superhydrophobic Coating
Radwan, A. Bahgat; Ibrahim, Magdy A.; Ismail, Eman H.; El Basiony, Nasser M.; El-Hout, Soliman I.; Zughaier, Susu M.; Hassiba, Maryam; Hassan, Mohammad K.; Okonkwo, Paul C.; Al-Qahtani, Noora; Abdullah, Aboubakr M.... more authors ... less authors ( American Chemical Society (ACS) , 2024 , Article)Aluminum is vulnerable to corrosion, biofouling, and durability reduction as a result of forming unwanted deposits during their interactions with liquids. In this work, a high-corrosion-resistance superhydrophobic coating ... -
ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein.
Mousa, Hanaa; Thanassoulas, Angelos; Zughaier, Susu M ( Elsevier , 2023 , Article)HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that ... -
Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation
Bagwe, Priyal; Bajaj, Lotika; Gala, Rikhav P.; D’souza, Martin J.; Zughaier, Susu M. ( MDPI , 2022 , Article)The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae ... -
Bi-attention DoubleUNet: A deep learning approach for carotid artery segmentation in transverse view images for non-invasive stenosis diagnosis
Najmath, Ottakath; Akbari, Younes; Al-Maadeed, Somaya Ali; Bouridane, Ahmed; Zughaier, Susu M.; Chowdhury, Muhammad E.H.... more authors ... less authors ( Elsevier , 2024 , Article)The carotid artery is a vital blood vessel that supplies oxygenated blood to the brain. Blockages in this artery can lead to life-threatening illnesses, making accurate diagnosis essential. While ultrasound (US) imaging ... -
Differentiation and classification of bacterial endotoxins based on surface enhanced Raman scattering and advanced machine learning
Yang, Yanjun; Xu, Beibei; Haverstick, James; Ibtehaz, Nabil; Muszyński, Artur; Chen, Xianyan; Chowdhury, Muhammad E.H.; Zughaier, Susu M.; Zhao, Yiping... more authors ... less authors ( Royal Society of Chemistry , 2022 , Article)Bacterial endotoxin, a major component of the Gram-negative bacterial outer membrane leaflet, is a lipopolysaccharide shed from bacteria during their growth and infection and can be utilized as a biomarker for bacterial ... -
Dynamics of Anti-S IgG Antibodies Titers after the Second Dose of COVID-19 Vaccines in the Manual and Craft Worker Population of Qatar
Bansal, Devendra; Atia, Hassan; Al Badr, Mashael; Nour, Mohamed; Abdulmajeed, Jazeel; Hasan, Amal; Al-Hajri, Noora; Ahmed, Lina; Ibrahim, Rumissa; Zamel, Reham; Mohamed, Almuthana; Pattalaparambil, Hamad; Daraan, Faisal; Chaudhry, Adil; Oraby, Sahar; El-Saleh, Sahar; El-Shafie, Sittana S.; Al-Farsi, Affra Faiz; Paul, Jiji; Ismail, Ahmed; Al-Romaihi, Hamad Eid; Al-Thani, Mohammed Hamad; Doi, Suhail A.R.; Zughaier, Susu M.; Cyprian, Farhan; Farag, Elmobashar; Farooqui, Habib Hasan... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)There is limited seroepidemiological evidence on the magnitude and long-term durability of antibody titers of mRNA and non-mRNA vaccines in the Qatari population. This study was conducted to generate evidence on long-term ... -
Editorial: Global excellence in children and health
Bener, Abdulbari; Tewfik, Ihab; Zughaier, Susu M.; Day, Andrew S. ( springer link , 2023 , Other)Cooperation and collaboration within and between countries is an increasingly important component of tackling and overcoming the pressing issues impacting upon children's health and wellbeing. This Research Topic (RT) aimed ... -
Editorial: Role of Iron in Bacterial Pathogenesis
Zughaier, Susu M.; Cornelis, Pierre ( Frontiers Media S.A. , 2018 , Article)Iron is the fourth-most abundant element on the earth, and it is needed by most organisms, including bacteria. It exists in two oxidation states, Fe2+ and Fe3+, and is involved in many oxido-reduction reactions (Andrews ... -
High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
Rinchai, Darawan; Deola, Sara; Zoppoli, Gabriele; Kabeer, Basirudeen Syed Ahamed; Taleb, Sara; Pavlovski, Igor; Maacha, Selma; Gentilcore, Giusy; Toufiq, Mohammed; Mathew, Lisa; Liu, Li; Vempalli, Fazulur Rehaman; Mubarak, Ghada; Lorenz, Stephan; Sivieri, Irene; Cirmena, Gabriella; Dentone, Chiara; Cuccarolo, Paola; Giacobbe, Daniele Roberto; Baldi, Federico; Garbarino, Alberto; Cigolini, Benedetta; Cremonesi, Paolo; Bedognetti, Michele; Ballestrero, Alberto; Bassetti, Matteo; Hejblum, Boris P.; Augustine, Tracy; Van Panhuys, Nicholas; Thiebaut, Rodolphe; Branco, Ricardo; Chew, Tracey; Shojaei, Maryam; Short, Kirsty; Feng, Carl G.; Zughaier, Susu M.; De Maria, Andrea; Tang, Benjamin; Hssain, Ali Ait; Bedognetti, Davide; Grivel, Jean Charles; Chaussabel, Damien... more authors ... less authors ( American Association for the Advancement of Science , 2022 , Article)Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via ... -
Impact of phthalate metabolites on vitamin D levels and subclinical inflammation: national health and nutrition examination survey, 2013–2018
Mahmoud, Elhassan; Elsayed, Abdalla Moustafa; Kaleem, Muhammad Zain; Alkorbi, Hamad A.; Elshoeibi, Amgad M.; Chivese, Tawanda; Zughaier, Susu M.... more authors ... less authors ( Taylor and Francis Ltd. , 2024 , Article)This study explores the association between phthalates and total vitamin D levels and the link between phthalates exposure and subclinical inflammation using monocyte percentage to high-density lipoprotein cholesterol ratio ... -
Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
Mousa, Hanaa; Elrayess, Mohamed A.; Diboun, Ilhame; Jackson, Simon K.; Zughaier, Susu M. ( MDPI , 2022 , Article)Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics ... -
Pathogenicity and virulence of monkeypox at the human-animal-ecology interface
Islam, Md Mazharul; Dutta, Pronesh; Rashid, Rijwana; Jaffery, Syed Shariq; Islam, Ariful; Farag, Elmoubashar; Zughaier, Susu M.; Bansal, Devendra; Hassan, Mohammad Mahmudul... more authors ... less authors ( Taylor & Francis , 2023 , Article)Monkeypox (Mpox) was mostly limited to Central and Western Africa, but recently it has been reported globally. The current review presents an update on the virus, including ecology and evolution, possible drivers of ... -
QCovSML: A reliable COVID-19 detection system using CBC biomarkers by a stacking machine learning model
Tawsifur, Rahman; Khandakar, Amith; Abir, Farhan Fuad; Faisal, Md Ahasan Atick; Hossain, Md Shafayet; Podder, Kanchon Kanti; Abbas, Tariq O.; Alam, Mohammed Fasihul; Kashem, Saad Bin; Islam, Mohammad Tariqul; Zughaier, Susu M.; Chowdhury, Muhammad E.H.... more authors ... less authors ( Elsevier , 2022 , Article)The reverse transcription-polymerase chain reaction (RT-PCR) test is considered the current gold standard for the detection of coronavirus disease (COVID-19), although it suffers from some shortcomings, namely comparatively ... -
Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study
Bibi, Zahra; Nawaz, Ahmed Daniyal; Al Kurbi, Maha; Fakhroo, Shahad; Ferih, Khaled; Al-Jaber, Noor; Alex, Merin; Elawad, Khalid H.; Chivese, Tawanda; Zughaier, Susu M.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Background: Despite the availability of a highly efficacious vaccine, varicella outbreaks are still being reported globally. In this study, we evaluated the real-world effectiveness of varicella vaccination among children ... -
Seroprevalence of camel brucellosis in Qatar
Alhussain, Hashim; Zughaier, Susu M.; Gawish, Ahmed; Mahmoud, Mahmoud H.; Yassine, Hadi M.; Al Thani, Asmaa; Obied, Tahra El; Al-Zeyara, Abdulaziz M.; Eltai, Nahla O.... more authors ... less authors ( Springer , 2022 , Article)Brucellosis is a significant zoonotic disease and one of the most common neglected diseases worldwide. It can infect a wide range of domestic and wild animal species. Infected animals are usually culled, causing substantial ... -
TB-CXRNet: Tuberculosis and Drug-Resistant Tuberculosis Detection Technique Using Chest X-ray Images
Rahman, Tawsifur; Khandakar, Amith; Rahman, Ashiqur; Zughaier, Susu M.; Al Maslamani, Muna; Chowdhury, Moajjem Hossain; Tahir, Anas M.; Hossain, Md Sakib Abrar; Chowdhury, Muhammad E.H.... more authors ... less authors ( Springer Nature , 2024 , Article)Tuberculosis (TB) is a chronic infectious lung disease, which caused the death of about 1.5 million people in 2020 alone. Therefore, it is important to detect TB accurately at an early stage to prevent the infection and ... -
Ultrasound Intima-Media Complex (IMC) Segmentation Using Deep Learning Models
Hassen Mohammed, Hanadi; Elharrouss, Omar; Ottakath, Najmath; Al-Maadeed, Somaya; Chowdhury, Muhammad E.H.; Bouridane, Ahmed; Zughaier, Susu M.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Common carotid intima-media thickness (CIMT) is a common measure of atherosclerosis, often assessed through carotid ultrasound images. However, the use of deep learning methods for medical image analysis, segmentation and ... -
Ventilator-associated pneumonia diagnosis: electrochemical sensors for rapid and sensitive detection of pyocyanin
Noorizadeh, Mohammad; Al-Hasan, Tamim M.; Sha, Mizaj S.; Bensaali, Faycal; Meskin, Nader; Sadasivuni, Kishor K.; Zughaier, Susu M.; Elgamal, Mahmoud; Hssain, Ali Ait... more authors ... less authors ( Springer Nature , 2024 , Article)Ventilator-associated pneumonia (VAP) is a severe condition in critically ill patients that requires timely diagnosis to improve patient outcomes. In this study, we developed an electrochemical sensor for pyocyanin detection ... -
Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia
Hanaa, Mousa; Al saei, Aisha; Razali, Rozaimi Mohamad; Zughaier, Susu M. ( Elsevier , 2024 , Article)Vitamin D deficiency and dyslipidemia have substantial implications for human health globally. Vitamin D is essential for bone metabolism and immune modulation, and its insufficiency is linked to various chronic inflammatory ...