Browsing by Author "Zughaier, Susu M."
Now showing items 1-20 of 25
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An Adjuvanted Inactivated SARS-CoV-2 Microparticulate Vaccine Delivered Using Microneedles Induces a Robust Immune Response in Vaccinated Mice
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)SARS-CoV-2, the causal agent of COVID-19, is a contagious respiratory virus that frequently mutates, giving rise to variant strains and leading to reduced vaccine efficacy against the variants. Frequent vaccination against ... -
Anticorrosion Properties of Robust and UV-Durable Poly(vinylidene fluoride-co-hexafluoropropylene)/Carbon Nanotubes Superhydrophobic Coating
( American Chemical Society (ACS) , 2024 , Article)Aluminum is vulnerable to corrosion, biofouling, and durability reduction as a result of forming unwanted deposits during their interactions with liquids. In this work, a high-corrosion-resistance superhydrophobic coating ... -
ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein.
( Elsevier , 2023 , Article)HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that ... -
Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation
( MDPI , 2022 , Article)The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae ... -
Bi-attention DoubleUNet: A deep learning approach for carotid artery segmentation in transverse view images for non-invasive stenosis diagnosis
( Elsevier , 2024 , Article)The carotid artery is a vital blood vessel that supplies oxygenated blood to the brain. Blockages in this artery can lead to life-threatening illnesses, making accurate diagnosis essential. While ultrasound (US) imaging ... -
DeepRaman: Implementing surface-enhanced Raman scattering together with cutting-edge machine learning for the differentiation and classification of bacterial endotoxins
( Elsevier , 2025 , Article)To classify raw SERS Raman spectra from biological materials, we propose DeepRaman, a new architecture inspired by the Progressive Fourier Transform and integrated with the scalogram transformation approach. Unlike standard ... -
Differentiation and classification of bacterial endotoxins based on surface enhanced Raman scattering and advanced machine learning
( Royal Society of Chemistry , 2022 , Article)Bacterial endotoxin, a major component of the Gram-negative bacterial outer membrane leaflet, is a lipopolysaccharide shed from bacteria during their growth and infection and can be utilized as a biomarker for bacterial ... -
Dynamics of Anti-S IgG Antibodies Titers after the Second Dose of COVID-19 Vaccines in the Manual and Craft Worker Population of Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)There is limited seroepidemiological evidence on the magnitude and long-term durability of antibody titers of mRNA and non-mRNA vaccines in the Qatari population. This study was conducted to generate evidence on long-term ... -
Editorial: Global excellence in children and health
( springer link , 2023 , Article)Cooperation and collaboration within and between countries is an increasingly important component of tackling and overcoming the pressing issues impacting upon children's health and wellbeing. This Research Topic (RT) aimed ... -
Editorial: Role of Iron in Bacterial Pathogenesis
( Frontiers Media S.A. , 2018 , Article)Iron is the fourth-most abundant element on the earth, and it is needed by most organisms, including bacteria. It exists in two oxidation states, Fe2+ and Fe3+, and is involved in many oxido-reduction reactions (Andrews ... -
The epidemiology of antimicrobial resistant bacterial infection in Qatar: A systematic review and meta-analysis
( Elsevier , 2025 , Article)BackgroundAntimicrobial resistance (AMR) is the current silent pandemic responsible for approximately five million deaths annually. According to the WHO, antimicrobial resistance is one of the top global public health ... -
Evaluating Nanoparticulate Vaccine Formulations for Effective Antigen Presentation and T-Cell Proliferation Using an In Vitro Overlay Assay
( PMC , 2024 , Article)Inducing T lymphocyte (T-cell) activation and proliferation with specificity against a pathogen is crucial in vaccine formulation. Assessing vaccine candidates’ ability to induce T-cell proliferation helps optimize formulation ... -
High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
( American Association for the Advancement of Science , 2022 , Article)Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via ... -
Impact of phthalate metabolites on vitamin D levels and subclinical inflammation: national health and nutrition examination survey, 2013–2018
( Taylor and Francis Ltd. , 2024 , Article)This study explores the association between phthalates and total vitamin D levels and the link between phthalates exposure and subclinical inflammation using monocyte percentage to high-density lipoprotein cholesterol ratio ... -
The interplay between vitamin D status, subclinical inflammation, and prediabetes
( Elsevier , 2024 , Article)Vitamin D's role extends beyond classical calcium and phosphate homeostasis to encompass a pivotal influence on immune modulation and metabolic health. The mechanisms by which vitamin D exerts these effects involve its ... -
Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
( MDPI , 2022 , Article)Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics ... -
Pathogenicity and virulence of monkeypox at the human-animal-ecology interface
( Taylor & Francis , 2023 , Article)Monkeypox (Mpox) was mostly limited to Central and Western Africa, but recently it has been reported globally. The current review presents an update on the virus, including ecology and evolution, possible drivers of ... -
QCovSML: A reliable COVID-19 detection system using CBC biomarkers by a stacking machine learning model
( Elsevier , 2022 , Article)The reverse transcription-polymerase chain reaction (RT-PCR) test is considered the current gold standard for the detection of coronavirus disease (COVID-19), although it suffers from some shortcomings, namely comparatively ... -
Real-World Effectiveness of the Varicella Vaccine among Children and Adolescents in Qatar: A Case–Control Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Background: Despite the availability of a highly efficacious vaccine, varicella outbreaks are still being reported globally. In this study, we evaluated the real-world effectiveness of varicella vaccination among children ... -
Recent Advances in Bacterial Detection Using Surface-Enhanced Raman Scattering
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Rapid identification of microorganisms with a high sensitivity and selectivity is of great interest in many fields, primarily in clinical diagnosis, environmental monitoring, and the food industry. For over the past decades, ...
