Browsing by Author "Alzu'bi, Ayman"
Now showing items 1-10 of 10
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Combining dopamine and vitamin E enhances the differentiation to cholinergic neurons of mesenchymal stem cells
( Oxford University Press , 2025 , Article)Recent research indicates that mesenchymal stem cells (MSCs) can transdifferentiate into neuron-like cells under specific conditions, offering promise for neuronal regeneration. However, challenges remain in optimizing ... -
Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59
( Korean Tissue Engineering and Regenerative Medicine Society , 2025 , Article)Background: Factor H and membrane inhibitor of reactive lysis (CD59) are key regulators of complement activation. Mesenchymal stem cells (MSCs) secrete Factor H and express CD59 to protect themselves from complement-mediated ... -
In vivo assessment of the nephrotoxic effects of the synthetic cannabinoid AB-FUBINACA
( Springer , 2024 , Article)Background: The widespread misuse of synthetic cannabinoids (SCs) has led to a notable increase in reported adverse effects, raising significant health concerns. SCs use has been particularly associated with acute kidney ... -
Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells
( Springer Nature , 2025 , Article)Background: Cancer cells can modulate the expression of many proteins that are essential for supporting their uncontrolled proliferation. Heat shock protein 90 (HSP90) is ubiquitously expressed in most cell types and ... -
The molecular mechanism of nitric oxide in memory consolidation and its role in the pathogenesis of memory-related disorders
( Springer Nature , 2025 , Article)Memory is a dynamic process of encoding, storing, and retrieving information. It includes sensory, short-term, and long-term memory, each with unique characteristics. Nitric oxide (NO) is a biological messenger synthesized ... -
Prevalence of SPOP and IDH Gene Mutations in Prostate Cancer in a Jordanian Population
( Springer , 2024 , Article)Speckle-type POZ (SPOP) is described as an essential tumor suppressor factor in gastric cancer, colorectal cancer, and prostate cancer (PCa). SPOP gene mutations were reported in primary human PCa. Isocitrate dehydrogenase-1 ... -
The synthetic cannabinoids menace: a review of health risks and toxicity
( Springer Nature , 2024 , Article)Synthetic cannabinoids (SCs) are chemically classified as psychoactive substances that target the endocannabinoid system in many body organs. SCs can initiate pathophysiological changes in many tissues which can be severe ... -
The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects
( Elsevier , 2024 , Article)Purpose: Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl ... -
The potential protective role of vitamin D and calcium supplements in reducing cardiovascular disease risk among elderly patients with osteopenia
( Springer Science and Business Media Deutschland GmbH , 2024 , Article)Background: Cardiovascular disease and low bone mineral density are major health problems in the elderly. These two conditions are considered independent of each other and age-related diseases. The aim of this study is to ... -
Therapeutic potential and challenges of mesenchymal stem cells in neurological disorders: A concise analysis
( Oxford University Press , 2025 , Article)Neurological diseases comprise a wide array of conditions affecting both the central and peripheral nervous systems. Neurodegenerative diseases encompass a group of debilitating and often fatal neurological disorders for ...
