Browsing by Author "Zaravinos, Apostolos"
Now showing items 1-6 of 6
-
Clinical significance of P-class pumps in cancer (Review)
Themistocleous, Sophia C.; Yiallouris, Andreas; Tsioutis, Constantinos; Zaravinos, Apostolos; Johnson, Elizabeth O.; Patrikios, Ioannis... more authors ... less authors ( Spandidos Publications , 2021 , Article)P-class pumps are specific ion transporters involved in maintaining intracellular/extracellular ion homeostasis, gene transcription, and cell proliferation and migration in all eukaryotic cells. The present review aimed ... -
DEFECTIVE NATURAL KILLER CELLS IN MELANOMA: ROLE OF NKG2D IN THE PATHOGENESIS AND IMMUNOTHERAPY
Bonavida, Benjamin; Touboul, Roni; Zaravinos, Apostolos ( Begell House , 2021 , Article)Melanoma is the most aggressive and deadliest form of skin cancer, and its prognosis is very poor. While the early detection is responsive to many treatments, metastatic melanoma is refractory to most of them. In the USA, ... -
Identification of Co-Deregulated Genes in Urinary Bladder Cancer Using High-Throughput Methodologies
Lambrou, George I.; Vichos, Kleanthis; Koutsouris, Dimitrios; Zaravinos, Apostolos ( MDPI , 2021 , Article)Urinary bladder cancer (UBC) is the second most common urogenital solid tumor and the eleventh in the rank among all types of solid tumors. Although several oncogenes and tumor suppressors are known to be implicated in the ... -
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
Roufas, Constantinos; Georgakopoulos-Soares, Ilias; Zaravinos, Apostolos ( Oxford University Press , 2021 , Article)Although immune checkpoint inhibition (ICI) has shown promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/MSS patients do not respond to such therapies. To systematically evaluate the ... -
RKIP in human diseases and its potential as a prognostic indicator and therapeutic target
Christofi, Theodoulakis; Zaravinos, Apostolos ( Elsevier , 2020 , Book chapter)The Raf kinase inhibitory protein (RKIP) is an inhibitor of the RAF/MEK/ERK and NF-κB signaling pathways, through which it regulates several key processes of the cell's physiology, such as its proliferation, motility and ... -
Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes.
Zaravinos, Apostolos; Gkretsi, Vasiliki; Andreas, Stylianou; Maria, Kalli; Maria, Louca; Chrysovalantis, Voutouri; Triantafyllos, Stylianopoulos... more authors ... less authors ( International Institute of Anticancer Research , 2020 , Article)As metastasis accounts for most breast cancer (BC)-related deaths, identifying key players becomes research priority. Growth differentiation factor-15 (GDF15), a member of the transforming growth factor-β superfamily, is ...