Browsing by Author "Baydoun, Elias"
Now showing items 1-13 of 13
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Determination of the Antioxidant and Antiproliferative Properties of Pomegranate Peel Extract Obtained by Ultrasound on HCT-116 Colorectal Cancer Cell Line
Habchi, Christie; Badran, Adnan; Srour, Mortada; Daou, Anis; Baydoun, Elias; Hamade, Kamar; Hijazi, Akram... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Colorectal cancer (CRC) is one of the most common cancers in the world. When treating patients, therapeutic agents have side effects; hence, the use of natural compounds found in medicinal plants including pomegranate. ... -
Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction
Fardoun, Manal M.; Issa, Khodr; Maaliki, Dina; Nasser, Suzanne A.; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Elsevier , 2020 , Article)Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α2C-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's ... -
Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
Mesmar, Joelle; Abdallah, Rola; Hamade, Kamar; Baydoun, Serine; Al-Thani, Najlaa; Shaito, Abdullah; Maresca, Marc; Badran, Adnan; Baydoun, Elias... more authors ... less authors ( Frontiers Media , 2022 , Article)Background: Breast cancer (BC) is the second most common cancer overall. In women, BC is the most prevalent cancer and the leading cause of cancer-related mortality. Triple-negative BC (TNBC) is the most aggressive BC, ... -
Flavonoids in adipose tissue inflammation and atherosclerosis: One arrow, two targets
Fardoun, Manal Muin; Maaliki, Dina; Halabi, Nabil; Iratni, Rabah; Bitto, Alessandra; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Portland Press Ltd , 2020 , Article Review)Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic ... -
Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer cells
Abdallah, Rola; Shaito, Abdullah A.; Badran, Adnan; Baydoun, Serine; Sobeh, Mansour; Ouchari, Wafae; Sahri, Nihad; Eid, Ali H.; Mesmar, Joelle Edward; Baydoun, Elias... more authors ... less authors ( Frontiers Media , 2024 , Article)Natural products have long been utilized in traditional medicine as remedies to improve health and treat illnesses, and have had a key role in modern drug discovery. Recently, there has been a revived interest in the search ... -
Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway.
Badran, Adnan; Baydoun, Elias; Samaha, Ali; Pintus, Gianfranco; Mesmar, Joelle; Iratni, Rabah; Issa, Khodr; Eid, Ali H... more authors ... less authors ( MDPI , 2019 , Article)Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden. is recognized ... -
MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes.
Dehaini, Hassan; Awada, Hussein; El-Yazbi, Ahmed; Zouein, Fouad A; Issa, Khodr; Eid, Assaad A; Ibrahim, Maryam; Badran, Adnan; Baydoun, Elias; Pintus, Gianfranco; Eid, Ali H... more authors ... less authors ( MDPI , 2019 , Article)Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), ... -
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
AlKahlout, Amal; Fardoun, Manal; Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; Nasser, Suzanne A.; Baydoun, Serine; Kobeissy, Firas; Shaito, Abdullah; Iratni, Rabah; Muhammad, Khalid; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Frontiers Media , 2022 , Article)Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ... -
Preventive and Therapeutic Effects of Punica granatum (Pomegranate) in Respiratory and Digestive Diseases: A Review
Alkhatib, Mariam; Fayad, Chantal; Badran, Adnan; Hamade, Kamar; Daou, Anis; Baydoun, Elias; Hijazi, Akram... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)The pomegranate fruit is made of white to deep purple seeds that are enclosed in a white, spongy, astringent membrane, also known as pericarp, covered by a thick red skin and a crown-shaped calyx. It contains a variety of ... -
Repurposing cilostazol for raynaud's phenomenon
El-Hachem, Nehme; Fardoun, Manal M.; Slika, Hasan; Baydoun, Elias; Eid, Ali H. ( Bentham Science Publishers , 2021 , Other)Raynaud's Phenomenon (RP) results from exaggerated cold-induced vasoconstriction. RP patients suffer from vasospastic attacks and compromised digital blood perfusion leading to a triple color change at the level the fingers. ... -
The Therapeutic Wound Healing Bioactivities of Various Medicinal Plants
Albahri, Ghosoon; Badran, Adnan; Hijazi, Akram; Daou, Anis; Baydoun, Elias; Nasser, Mohamad; Merah, Othmane... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)The skin serves as the body’s first line of defense, guarding against mechanical, chemical, and thermal damage to the interior organs. It includes a highly developed immune response that serves as a barrier against pathogenic ... -
Ziziphus nummularia attenuates the malignant phenotype of human pancreatic cancer cells: Role of ros
Mesmar, J.; Mesmar, Joelle; Fardoun, Manal M.; Abdallah, Rola; Al Dhaheri, Yusra; Yassine, Hadi M.; Iratni, Rabah; Badran, Adnan; Eid, Ali H.; Baydoun, Elias... more authors ... less authors ( MDPI AG , 2021 , Article)Pancreatic cancer (PC) is the fourth leading cause of all cancer-related deaths. Despite major improvements in treating PC, low survival rate remains a major challenge, indicating the need for alternative approaches, ... -
Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties
Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; Maresca, Marc; Shaito, Abdullah; Baydoun, Elias... more authors ... less authors ( MDPI , 2022 , Article Review)Ziziphus nummularia, a small bush of the Rhamnaceae family, has been widely used in traditional folk medicine, is rich in bioactive molecules, and has many reported pharmacological and therapeutic properties. Objective: ...